Rabbit anti Human aurora-B kinase antibody
recognizes aurora kinase B (AURKB), also known as AIK2, AIM1, STK1. The Aurora kinases are serine/threonine kinases that regulate chromosomal alignment and segregation during mitosis and meiosis. Aurora B kinase interacts with INCENP and Survivin, and is involved with control of cytokinesis and chromosome bi-orientation during mitosis (Shannon and Salmon 2002
). Accordingly, abundance of Aurora B kinase is regulated by the cell cycle and localizes to the centromeres from the prophase to metaphase-anaphase transition (Yu et al. 2017). The tumor suppressor p53, known as the "guardian" of the cell cycle, can be phosphorylated and degraded by Aurora B kinase (Gully et al. 2012
). Aurora B is overexpressed in many primary tumors, may contribute to cancer pathogenesis through tetraploidy and genetic instability (Goldenson and Crispino 2015
), and has been linked to poor prognosis. Aurora B kinase inhibitors have been suggested as anti-cancer treatments (Yu et al. 2017
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Aurora-B Kinase antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.