Androgen Receptor antibody | RM254
Rabbit anti Androgen Receptor
- Product Type
- Monoclonal Antibody
- Clone
- RM254
- Isotype
- IgG
- Specificity
- Androgen Receptor
Antibody Quality and Performance Guarantee
| Rabbit anti Human androgen receptor antibody recognizes androgen receptor (AR), also known as Dihydrotestosterone receptor (DHTR), NR3C4. Androgen Receptor is a ligand-activated transcription factor that belongs to a large family of nuclear receptor proteins. Unbound Androgen Receptor resides predominately in the cytoplasm as a heteromeric complex with hsp90 and other chaperone proteins. Circulating testosterone is converted to dihydrotestosterone (DHT) which binds to androgen receptor in the cytoplasm, releasing androgen receptor from its inhibition with HSPs and allowing translocation to the nucleus, where androgen receptor can initiate transcription of its target genes (Tan et al. 2015). Androgen signaling plays a role in pathogenesis of prostate cancer, and gonadal depletion of androgens is a central therapy for advanced prostate cancer. However, progression to castration-resistant prostate cancer has led to development of therapies that directly target the androgen receptor (Dai et al. 2017) Androgen receptor also seems to play a major role in carcinogenesis of triple negative breast cancer (TNBC), a very aggressive cancer type which comprises 15 to 20% of all breast cancers (Gerratana et al. 2018). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the N-terminus of androgen receptor
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/1000 | 1/2500 |
| Western Blotting | |
1/100 | 1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P10275
- Entrez Gene
- AR
- GO Terms
- GO:0016049 cell growth
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0005102 receptor binding
- GO:0004882 androgen receptor activity
- GO:0005497 androgen binding
- GO:0005737 cytoplasm
- GO:0005654 nucleoplasm
- GO:0006810 transport
- GO:0007267 cell-cell signaling
- View More GO Terms
- GO:0008013 beta-catenin binding
- GO:0008134 transcription factor binding
- GO:0008219 cell death
- GO:0008270 zinc ion binding
- GO:0008283 cell proliferation
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010843 promoter binding
- GO:0016563 transcription activator activity
- GO:0019899 enzyme binding
- GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
- GO:0046983 protein dimerization activity
MCA6308
155780
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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