AMPK Alpha 1 antibody | RM301
Rabbit anti AMPK Alpha 1
- Product Type
- Monoclonal Antibody
- Clone
- RM301
- Isotype
- IgG
- Specificity
- AMPK Alpha 1
Rabbit anti Human AMPK alpha 1 antibody recognizes 5'-AMP-activated protein kinase catalytic subunit alpha-1, also known as PRKAA1, AMPK1. AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit (alpha 1 and alpha 2), which is stabilized by non-catalytic regulatory beta- and gamma- subunits (Yan et al. 2018). AMPK responds to changes in intracellular adenine nucleotide levels, regulating cellular energy balance. AMPK is activated by an increase in AMP/ADP relative to ATP, and leads to an increase in rate of catabolic (ATP-generating) pathways and decreases rate of anabolic (ATP-utilizing) pathways (Carling et al. 2017). This results in maintenance of cellular energy homeostasis under conditions of hypoxia, low glucose levels, oxidative stress. Evidence suggests that AMPK acts as a tumor suppressor and has been suggested as a target for therapy, opposing tumor progression in several cancer types in part by regulating metabolism and inflammation (Li et al. 2015). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the residues near the C-terminus of Human AMPK alpha 1
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin | 1/100 | 1/200 | |
Western Blotting | 1/100 | 1/200 |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml | Log in | |||
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Description | Sheep anti Rabbit IgG:RPE |
- UniProt
- Q13131
- Entrez Gene
- PRKAA1
- GO Terms
- GO:0000187 activation of MAPK activity
- GO:0005515 protein binding
- GO:0001666 response to hypoxia
- GO:0005829 cytosol
- GO:0004691 cAMP-dependent protein kinase activity
- GO:0046872 metal ion binding
- GO:0005524 ATP binding
- GO:0006633 fatty acid biosynthetic process
- GO:0006695 cholesterol biosynthetic process
- View More GO Terms
- GO:0007050 cell cycle arrest
- GO:0008286 insulin receptor signaling pathway
- GO:0045542 positive regulation of cholesterol biosynthetic process
- GO:0045768 positive regulation of anti-apoptosis
- GO:0046318 negative regulation of glucosylceramide biosynthetic process
- GO:0046320 regulation of fatty acid oxidation
MCA6327
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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