ALIX antibody | OTI1A4
Mouse anti ALIX
- Product Type
- PrecisionAb Monoclonal
- Clone
- OTI1A4
- Isotype
- IgG2a
- Format
- Purified
- Specificity
- ALIX
Antibody Quality and Performance Guarantee
| Mouse anti Human ALIX antibody recognizes the programmed cell death 6-interacting protein, also known as ALG-2 interacting protein 1, ALG-2-interacting protein X, PDCD6-interacting protein, apoptosis-linked gene 2-interacting protein X, dopamine receptor interacting protein 4 and programmed cell death 6-interacting protein. The PDCD6IP (ALIX) gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Overexpression of murine ALIX can block apoptosis. In addition, the product of PDCD6IP binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. PDCD6IP (ALIX) product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of PDCD6IP product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for PDCD6IP. Related pseudogenes have been identified on chromosome 15 (provided by RefSeq, Jan 2012). Mouse anti Human ALIX antibody detects a band of 96 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
|
- Target Species
- Human
- Western Blotting
- Anti ALIX detects a band of approximately 96 kDa in K562 cell lysates.
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody purified by affinity chromatography from ascites.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
≤50% Glycerol - Immunogen
- Full length recombinant human ALIX (NP_037506) produced in HEK293T cells
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml.
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- Q8WUM4
- Entrez Gene
- PDCD6IP
- GO Terms
- GO:0006915 apoptosis
- GO:0005829 cytosol
- GO:0005815 microtubule organizing center
- GO:0007049 cell cycle
- GO:0015031 protein transport
- GO:0042470 melanosome
- GO:0044419 interspecies interaction between organisms
- GO:0048306 calcium-dependent protein binding
- GO:0051301 cell division
- View More GO Terms
VMA00273
151318
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