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Certolizumab Pegol antibody | AbD34201ia

Human anti Certolizumab Pegol

Product Type
Monoclonal Antibody
Certolizumab Pegol

Product Code Applications Pack Size List Price Your Price Qty
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.1 mg loader
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Human Anti-Certolizumab pegol Antibody, clone AbD34201ia, is a paratope specific, inhibitory anti-idiotypic antibody that specifically recognizes the free humanized Fab fragment antibody certolizumab pegol. The antibody does not recognize human Tumor Necrosis Factor alpha (TNFα) or certolizumab pegol in complex with human TNFα.

Clone AbD34201ia is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or reference standard in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 1 nM, and is one of three antibodies with different affinities offered for ADA assays. Antibody HCA324 has affinity 3 nM and HCA326 has affinity 2 nM.

Certolizumab pegol (Cimzia) is a humanized Fab fragment antibody (50 kDa), covalently bound to two polyethylene glycol (PEG) chains (PEG2MAL, 40 kDa) via a thioether linkage; total molecular weight 90.8 kDa. PEG helps to delay the metabolism and elimination of the drug. The removal of the Fc region increases the half-life of the drug and prevents complement fixation and antibody-mediated cytotoxicity. The drug is approved for the treatment of Crohn's disease, rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. It binds to free and membrane-bound human TNFα and neutralizes its activity by inhibiting the binding of TNFα to human p55 and p75 TNF receptors.

View a summary of all anti-certolizumab pegol antibodies
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Product Form
Human IgG1 antibody (kappa light chain) selected from the HuCAL phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Certolizumab pegol
The intrinsic affinity of the monovalent form of Human anti Certolizumab Pegol antibody, clone AbD34201ia is KD = 1 nM as measured by real time, label free molecular interaction analysis on immobilized Certolizumab Pegol.
Approx. Protein Concentrations
Antibody concentration 0.5 mg/ml
For research purposes only
12 months from date of despatch
This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See for details.
Cimzia is a trademark of UCB Pharma S.A.
Licensed Use
For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Technical Advice
Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
Human anti Certolizumab Pegol antibody, clone AbD34136ia can be used in an indirect ELISA. It can also be used as a surrogate positive control or calibrator in an anti-drug antibody assay.
Protocol: ADA bridging ELISA.

Description Product Code Applications Pack Size List Price Your Price Quantity
Hispec Assay Diluent BUF049A E IY 50 ml
List Price Your Price
Description Hispec Assay Diluent
Human anti Certolizumab Pegol HCA324 E 0.1 mg loader
List Price Your Price
Description Human anti Certolizumab Pegol
Human anti Certolizumab Pegol HCA326 E 0.1 mg loader
List Price Your Price
Description Human anti Certolizumab Pegol
LYNX Rapid HRP Antibody Conjugation Kit LNK002P CJ 3 Conjugations For 400µg Antibody
List Price Your Price
Description LYNX Rapid HRP Antibody Conjugation Kit



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View more products with CERTOLIZUMAB PEGOL specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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