Canakinumab antibody | AbD54111ia




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E ResetHuman anti Canakinumab
- Product Type
- Monoclonal Antibody
- Clone
- AbD54111ia
- Isotype
- IgG1
- Specificity
- Canakinumab
Human Anti-Canakinumab Antibody, clone AbD54111ia is a paratope specific, inhibitory, anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug canakinumab, and its biosimilar products. It does not recognize the drug target, interleukin-1 beta (IL-1β), nor canakinumab in complex with IL-1β. This antibody can be used to measure free canakinumab levels in serum from patients. HCA418 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 7.7nM and is one of the three antibodies offered for ADA assays. Antibody HCA417 has an affinity of 1.5nM and HCA419 has an affinity of 9.6nM. Canakinumab (trade name Ilaris) is a fully humanized monoclonal IgG1/kappa antibody with allotype G1m3. It binds to interleukin-1 beta (IL-1β) to neutralize up-regulated 1β signaling, resulting in suppression of inflammation in patients with disorders of autoimmune origin. Canakinumab is indicated for treatment of Cryopyrin-Associated Periodic Syndromes (CAPS), three rare and serious auto-inflammatory diseases, Still’s disease, and gouty arthritis. |
- Product Form
- Human IgG1 antibody (kappa light chain) selected from the HuCAL phage display library and expressed in a human cell line. This product is supplied as a liquid.
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Source
- HKB-11
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Canakinumab
- Affinity
- The intrinsic affinity of the monovalent form of Human Anti-Canakinumab Antibody, clone AbD54111ia is KD = 7.7 nM as measured by real time, label free molecular interaction analysis on immobilized canakinumab
- Approx. Protein Concentrations
- Antibody concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Ilaris is a trademark of Novartis AG. - Licensed Use
- For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
- Clone AbD54111ia can be used in indirect ELISA to detect canakinumab. It can also be used as a surrogate positive control or a calibrator in an anti-drug antibody (ADA) assay, together with HCA417 and HCA419
Protocol: ADA bridging ELISA
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Hispec Assay Diluent | BUF049A | E IY | 50 ml | Log in | |||
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Description | Hispec Assay Diluent | ||||||
Human anti Canakinumab | HCA417 | E | 0.1 mg |
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Description | Human anti Canakinumab | ||||||
Human anti Canakinumab | HCA419 | E | 0.1 mg |
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Description | Human anti Canakinumab | ||||||
LYNX Rapid HRP Antibody Conjugation Kit | LNK002P | CJ | 3 Conjugations For 400µg Antibody | Log in | |||
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Description | LYNX Rapid HRP Antibody Conjugation Kit | ||||||
Human anti Canakinumab | TZA063 | E | 0.1 mg |
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Description | Human anti Canakinumab | ||||||
Human anti Canakinumab | TZA064 | E | 0.1 mg |
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Description | Human anti Canakinumab |
- Synonyms
- Ilaris
HCA418

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