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Belatacept antibody | AbD37060

Human anti Belatacept

Product Type
Monoclonal Antibody
Fab antibody

Product Code Applications Pack Size List Price Your Price Qty
New HCA391
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.1 mg
List Price Your Price

Human Anti-Belatacept Antibody, clone AbD37060 is an affinity-matured, inhibitory, anti-idiotypic antibody. It recognizes the drugs belatacept and abatacept, and their biosimilar products as well as cytotoxic T-lymphocyte antigen-4 (CTLA-4), also known as CD152. The antibody binds to free belatacept, abatacept and human CTLA4 and can be used to measure free belatacept, abatacept or their biosimilars in patient samples.

Clone AbD37060 is a monoclonal antibody with Fab isotype and is suitable as a positive control or as capture antibody for Belatacept in a PK bridging ELISA. This clone is also available in a full length hIgG1 format (HCA392)

This Anti-Belatacept Antibody cross-reacts with the drug abatacept (Orencia). It is only 2 amino acids different from abatacept. LEA29Y-belatacept was constructed by two amino acid substitutions (L104E and A29Y) compared to abatacept that gave rise to slower dissociation rates for both CD86 and CD80.

Belatacept (Nulojix) is a genetically engineered fusion protein which consists of the functional binding domain of modified human CTLA-4 and the Fc domain of human monoclonal immunoglobulin of the IgG1 subclass. The Fc part has the allotype IGHG1*05. Belatacept is indicated for prophylaxis of organ rejection in adult patients receiving a kidney transplant. It is to be used in combination with basiliximab induction, mycophenolate mofetil, and corticosteroids.

View a summary of all anti-belatacept antibodies

Product Form
A monovalent human recombinant Fab (kappa light chain) selected from the HuCAL® phage display library, expressed in E. coli. The antibody is tagged with a DYKDDDDK tag and a HIS-tag (HHHHHH) at the C-terminus of the antibody heavy chain. This antibody is supplied as a liquid.
Metal chelate affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
The intrinsic affinity of the monovalent form of Human anti Belatacept antibody, clone AbD37060 is KD = 0.6 nM as measured by real time, label free molecular interaction analysis on immobilized Belatacept..
Approx. Protein Concentrations
Antibody concentration 0.5 mg/ml
For research purposes only
12 months from date of despatch
This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See for details.
His-tag is a registered trademark of EMD Biosciences.
Nulojix is a trademark of Bristol-Myers Squibb Company.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Technical Advice
Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
Human anti Belatacept antibody, clone AbD37060 can be used in a direct or indirect ELISA. It can also be used as a capture antibody for belatacept in a PK bridging ELISA together with HCA393P as the detection reagent.

PK bridging ELISA

Description Product Code Applications Pack Size List Price Your Price Quantity
Hispec Assay Diluent BUF049A E IY 50 ml
List Price Your Price
Description Hispec Assay Diluent
Human anti Belatacept HCA392 E 0.1 mg
List Price Your Price
Description Human anti Belatacept
Human anti Belatacept HCA393 E 0.1 mg
List Price Your Price
Description Human anti Belatacept
LYNX Rapid HRP Antibody Conjugation Kit LNK002P CJ 3 Conjugations For 400µg Antibody
List Price Your Price
Description LYNX Rapid HRP Antibody Conjugation Kit

Licensed Use
For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.



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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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