Anti-Nirsevimab Antibodies
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Bioanalytical Antibodies
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Antibodies for Bioanalysis and Drug Monitoring
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Antibodies for Bioanalysis and Drug Monitoring
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Antibodies for bioanalysis and drug monitoring of nirsevimab and biosimilars
Develop highly selective and sensitive PK and ADA assays for the humanized antibody drug nirsevimab (Beyfortus®) using our range of ready-made anti-idiotypic antibodies.
- Inhibitory antibodies specific to nirsevimab
- Fully human surrogate positive control or calibrator
- Sequence defined, well characterized reagents with secure supply
- Recombinant production, stringent quality control for batch-to-batch consistency
- Non-animal-derived antibodies, reducing the use of animals in science
Table 1. Antibodies Specific to Nirsevimab.
Specificity |
Catalog Number |
Clone |
Format |
Affinity* KD, nM |
Assay Recommendation |
Product Details |
|---|---|---|---|---|---|---|
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Nirsevimab Inhibitory Type 1 |
HCA450 |
AbD64623ia |
Human IgG1 |
0.1 |
ADA assay |
Order HCA450 |
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HCA451 |
AbD64625ia |
Human IgG1 |
0.5 |
ADA assay |
Order HCA451 |
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|
HCA452 |
AbD64626ia |
Human IgG1 |
2.7 |
ADA assay |
Order HCA452 |
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|
TZA0147 |
AbD64623ad |
Fab-F-Spy2-H1 |
0.1 |
PK bridging ELISA (capture) |
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|
TZA0148 |
AbD64624ad |
Fab-F-Spy2-H1 |
0.3 |
PK bridging ELISA (detection) |
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|
TZA0148P |
AbD64624pap |
Fab2-FH-X22-HRP2 |
0.3 |
PK bridging ELISA (detection) |
* Affinity measured in the monovalent Fab format.
1 Fab-F-Spy2-H = Monovalent Fab antibody with (F) DYKDDDDK, (Spy2) SpyTag version 2, and (H) His-6-tags.
2 Fab2-FH-X22-HRP = Bivalent Fab antibody with (F) DYKDDDDK, (H) His-6-tags, and Fab-SpyTag coupled to HRP-conjugated BiCatcher.
Anti-Nirsevimab Inhibitory Antibodies (Type 1)
Type 1 anti-nirsevimab antibodies inhibit the binding of the drug nirsevimab to its target, fusion glycoprotein F0 of respiratory syncytial virus (RSV). They are ideal for development of a pharmacokinetic (PK) bridging ELISA to measure free drug. In fully human IgG1 format, they are suitable as a surrogate positive control or calibrator for an anti-drug antibody (ADA) assay.
ELISA Protocols to Get You Started
PK Bridging ELISA
Fig. 1. Nirsevimab PK bridging ELISA using antibodies TZA0147 (capture) and TZA0148P (detection).
Schematic image of PK bridging ELISA detecting free drug. Anti-idiotypic capture antibody, Fab format (purple), monoclonal antibody drug (gold), anti-idiotypic detection antibody, Fab format (purple), labeled with HRP.
ADA Bridging ELISA
Fig. 2. Nirsevimab ADA bridging ELISA using antibodies HCA450, HCA451, and HCA452.
Schematic image of ADA bridging assay. Monoclonal antibody drug as capture antibody and detection antibody labeled with HRP (gold), fully human anti-idiotypic antibody, Ig format (blue).
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