Anti-Isatuximab Antibodies
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- Anti-Isatuximab Antibodies
- Anti-Isatuximab Inhibitory Antibodies (Type 1)
- ELISA Protocols to Get You Started
- Resources
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Bioanalytical Antibodies
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Antibodies for Bioanalysis and Drug Monitoring
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Our Anti-Biotherapeutic Antibodies
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- Anti-Isatuximab Antibodies
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Our Anti-Biotherapeutic Antibodies
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Antibodies for Bioanalysis and Drug Monitoring
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Antibodies for bioanalysis and drug monitoring of isatuximab
Develop highly selective and sensitive PK and ADA assays for the humanized antibody drug isatuximab (Sarclisa®) using our range of ready-made anti-idiotypic antibodies.
- Recombinant inhibitory antibodies specific to isatuximab
- TrailBlazer™ Antibodies enabling site-directed conjugation and format switching
- Fully human surrogate positive control or calibrator
- Sequence defined, well characterized reagents with secure supply
- Recombinant production, stringent quality control for batch-to-batch consistency
- Non-animal-derived antibodies, reducing the use of animals in science
Table 1. Antibodies Specific to Isatuximab.
| Specificity Binding Type |
Catalog Number | Clone | Format | Affinity* KD, nM | Assay Recommendation | Product Details |
|---|---|---|---|---|---|---|
|
Isatuximab Inhibitory Type 1 |
TZA0124 | AbD64599ad | Fab-F-Spy2-H1 | 1.0 |
PK bridging ELISA (capture) |
Order TZA0124 |
| TZA0125 | AbD64592ad | Fab-F-Spy2-H1 | 1.0 |
PK bridging ELISA (detection) |
Order TZA0125 | |
| TZA0125P | AbD64592pap | Fab2-FH-X22-HRP2 | 1.0 |
PK bridging ELISA (detection) |
* Affinity measured in the monovalent Fab format.
1 Fab-F-Spy2-H = Monovalent Fab antibody with (F) DYKDDDDK, (Spy2) SpyTag version 2, and (H) His-6-tags.
2 Fab2-FH-X22-HRP = Bivalent Fab antibody with (F) DYKDDDDK, (H) His-6-tags, and Fab-SpyTag coupled to HRP-conjugated BiCatcher.
Anti-Isatuximab Inhibitory Antibodies (Type 1)
Type 1 anti-isatuximab antibodies inhibit the binding of the drug isatuximab to its target, CD38. They are ideal for the development of a pharmacokinetic (PK) bridging ELISA to measure free drug. In a fully human IgG1 format, they are suitable as a surrogate positive control or calibrator for an anti-drug antibody (ADA) assay.
ELISA Protocols to Get You Started
PK Bridging ELISA
Fig. 1. Isatuximab PK bridging ELISA using antibodies TZA0124 (capture) and TZA0125P (detection).
Schematic image of PK bridging ELISA detecting free drug. Anti-idiotypic capture antibody, Fab format (purple), monoclonal antibody drug (gold), anti-idiotypic detection antibody, Fab format (purple), labeled with HRP.
Resources
Licensed Use: For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.