Sex Hormone Binding Globulin
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Purified Human sex hormone binding globulin, is a ~90 kDa homodimeric glycoprotein composed of two 45 kDa subunits linked via disulphide bridges. It is an androgen transport protein which binds and regulates the free concentration of steroid hormones and is involved in steroid signalling at the cell membrane.
Product Details
- Target Species
- Human
- Product Form
- Purified human sex hormone binding globulin - liquid
- Preparation
- Purified human sex hormone binding globulin from human serum plasma.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Purity
- >90% by SDS PAGE
- Approx. Protein Concentrations
- Total protein concentration 1.0 mg/ml
- Protein Molecular Weight
- 45 kDa
Storage Information
- Storage
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 18 months from date of despatch
More Information
- UniProt
- P04278
- Entrez Gene
- SHBG
- GO Terms
- GO:0005576 extracellular region
- GO:0005497 androgen binding
- GO:0009914 hormone transport
- GO:0042803 protein homodimerization activity
- Regulatory
- For research purposes only
Applications of Sex Hormone Binding Globulin
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | |||
| Immunoassay |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2020 Bio-Rad Antibodies (formerly AbD Serotec)
Product Specific References
References for Sex Hormone Binding Globulin
-
Rosner, W. et al. (1999) Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane.
J Steroid Biochem Mol Biol. 69 (1-6): 481-5. -
Kahn, S.M. et al. (2002) Sex hormone-binding globulin is synthesized in target cells.
J Endocrinol. 175 (1): 113-20. -
Zheng, X. et al. (2015) Analysis of Hormone-Protein Binding in Solution by Ultrafast Affinity Extraction: Interactions of Testosterone with Human Serum Albumin and Sex Hormone Binding Globulin.
Anal Chem. 87 (22): 11187-94.
