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Sex Hormone Binding Globulin

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Purified Human Sex Hormone Binding Globulin

Product Type
Purified Protein
Specificity
Sex Hormone Binding Globulin

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Purified Human sex hormone binding globulin, is a ~90 kDa homodimeric glycoprotein composed of two 45 kDa subunits linked via disulphide bridges. It is an androgen transport protein which binds and regulates the free concentration of steroid hormones and is involved in steroid signalling at the cell membrane.

Target Species
Human
Product Form
Purified human sex hormone binding globulin - liquid
Preparation
Purified human sex hormone binding globulin from human serum plasma.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Purity
>90% by SDS PAGE
Approx. Protein Concentrations
Total protein concentration 1.0 mg/ml
Protein Molecular Weight
45 kDa
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunoassay
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for Sex Hormone Binding Globulin

  1. Zheng, X. et al. (2015) Analysis of Hormone-Protein Binding in Solution by Ultrafast Affinity Extraction: Interactions of Testosterone with Human Serum Albumin and Sex Hormone Binding Globulin.
    Anal Chem. 87 (22): 11187-94.

Further Reading

  1. Rosner, W. et al. (1999) Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane.
    J Steroid Biochem Mol Biol. 69 (1-6): 481-5.
  2. Kahn, S.M. et al. (2002) Sex hormone-binding globulin is synthesized in target cells.
    J Endocrinol. 175 (1): 113-20.

Synonyms
SHBG
UniProt
P04278
Entrez Gene
SHBG
GO Terms
GO:0005576 extracellular region
GO:0005497 androgen binding
GO:0009914 hormone transport
GO:0042803 protein homodimerization activity

PHP147

160609 160616

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