Sex Hormone Binding Globulin

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Purified Human Sex Hormone Binding Globulin

Product Type
Purified Protein
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
PHP147 E IY 0.1 mg
Purified Human sex hormone binding globulin, is a ~90 kDa homodimeric glycoprotein composed of two 45 kDa subunits linked via disulphide bridges. It is an androgen transport protein which binds and regulates the free concentration of steroid hormones and is involved in steroid signalling at the cell membrane.

Product Details

Target Species
Human
Product Form
Purified human sex hormone binding globulin - liquid
Preparation
Purified human sex hormone binding globulin from human serum plasma.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Purity
>90% by SDS PAGE
Approx. Protein Concentrations
Total protein concentration 1.0mg/ml
Molecular Weight
45kD

Storage Information

Storage
Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P04278 Related reagents
Entrez Gene
SHBG Related reagents
GO Terms
GO:0005576 extracellular region
GO:0005497 androgen binding
GO:0009914 hormone transport
GO:0042803 protein homodimerization activity
Regulatory
For research purposes only

Applications of Sex Hormone Binding Globulin

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunoassay
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Product Specific References

References for Sex Hormone Binding Globulin

  1. Rosner, W. et al. (1999) Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane.
    J. Steroid Biochem. Mol. Biol. 69: 481-485.
  2. Kahn, S. et al. (2002) Sex hormone-binding globulin is synthesized in target cells.
    J. Endocrinol. 175: 113–120.
  3. Zheng X et al. (2015) Analysis of Hormone-Protein Binding in Solution by Ultrafast Affinity Extraction: Interactions of Testosterone with Human Serum Albumin and Sex Hormone Binding Globulin.
    Anal Chem. Oct 20. [Epub ahead of print]