Prostate Specific Antigen
Native Human prostate specific antigen demonstrates high specific activity and low levels of any contaminating proteins, including those with trypsin-like protease activity (Manning et al. 2012).
- Target Species
- Product Form
- Purified protein from human seminal fluid - liquid
- Sterlie filtered through a 0.2 µM membrane
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Pack Size: 0.2 mg>40% by SDS-PAGEPack Size: 0.1 mg>96% by SDS-PAGE
- Approx. Protein Concentrations
- 1.0 mg/ml
- Protein Molecular Weight
- 30 kDa
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the protein. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
- GO:0004252 serine-type endopeptidase activity
- GO:0005576 extracellular region
- GO:0006508 proteolysis
- GO:0016525 negative regulation of angiogenesis
- For research purposes only
Applications of Prostate Specific Antigen
|Application Name||Verified||Min Dilution||Max Dilution|
Product Specific References
References for Prostate Specific Antigen
Manning, M,L, et al. (2012) Trypsin-like proteolytic contamination of commercially available psa purified from human seminal fluid.
Prostate. 72 (11): 1233-8.
Arya, S.K. and Bhansali, S. (2012) Anti-Prostate Specific Antigen (Anti-PSA) Modified Interdigitated Microelectrode-Based Impedimetric Biosensor for PSA Detection
Biosensors Journal 1: H110601
Chornokur, G. et al. (2011) Impedance-Based Miniaturized Biosensor for Ultrasensitive and Fast Prostate-Specific Antigen Detection
Journal of Sensors, vol. 2011, Article ID 983752
Manning ML et al. (2013) Proteolysis of complement factors iC3b and C5 by the serine protease prostate-specific antigen in prostatic fluid and seminal plasma.
J Immunol. 190 (6): 2567-74.
Piletska, E.V. et al. (2014) Microplates with enhanced immobilization capabilities controlled by a magnetic field
J Chin Adv Mat Soc. 2: 118-29.
Isaacs, J.T. et al. (2018) SYNTHETIC ENHANCEMENT OF THE T-CELL ARMAMENTARIUM AS AN ANTI-CANCER THERAPY
US Patent application 20180148480 A1
Li, H. et al. (2020) Comprehensive role of prostate‐specific antigen identified with proteomic analysis in prostate cancer
J Cell Mol Med. 27 Jul. [Epub ahead of print].
Kostova, M.B. et al. (2018) PSA-alpha-2-macroglobulin complex is enzymatically active in the serum of patients with advanced prostate cancer and can degrade circulating peptide hormones.
Prostate. 78 (11): 819-29.
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