Prostate Specific Antigen

Native Human Prostate Specific Antigen

Product Type
Purified Protein
Prostate Specific Antigen

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SDS Safety Datasheet SDS
E 0.2 mg loader
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SDS Safety Datasheet SDS
E WB 0.1 mg loader
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Native Human prostate specific antigen preparation is a purified form of human prostate-specific antigen (PSA), a glycoprotein of ~30 kDa found mainly in prostatic tissue and seminal fluid. PSA is also present in small quantities in the serum of normal men and is often elevated in the presence of prostate cancer and in other prostatic disorders.

Native Human prostate specific antigen demonstrates high specific activity and low levels of any contaminating proteins, including those with trypsin-like protease activity (Manning et al. 2012).

Target Species
Product Form
Purified protein from human seminal fluid - liquid
7820-0604: Sterile filtered through a 0.2 µM membrane
7820-0504: Sterlie filtered through a 0.2 µM membrane
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Pack Size: 0.2 mg
>40% by SDS-PAGE
Pack Size: 0.1 mg
>96% by SDS-PAGE
Approx. Protein Concentrations
1.0 mg/ml
Protein Molecular Weight
30 kDa
For research purposes only
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the protein. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

References for Prostate Specific Antigen

  1. Manning, M,L, et al. (2012) Trypsin-like proteolytic contamination of commercially available psa purified from human seminal fluid.
    Prostate. 72 (11): 1233-8.
  2. Arya, S.K. and Bhansali, S. (2012) Anti-Prostate Specific Antigen (Anti-PSA) Modified Interdigitated Microelectrode-Based Impedimetric Biosensor for PSA Detection
    Biosensors Journal 1: H110601
  3. Chornokur, G. et al. (2011) Impedance-Based Miniaturized Biosensor for Ultrasensitive and Fast Prostate-Specific Antigen Detection
    Journal of Sensors, vol. 2011, Article ID 983752
  4. Manning ML et al. (2013) Proteolysis of complement factors iC3b and C5 by the serine protease prostate-specific antigen in prostatic fluid and seminal plasma.
    J Immunol. 190 (6): 2567-74.
  5. Piletska, E.V. et al. (2014) Microplates with enhanced immobilization capabilities controlled by a magnetic field
    J Chin Adv Mat Soc. 2: 118-29.
    US Patent application 20180148480 A1
  7. Li, H. et al. (2020) Comprehensive role of prostate‐specific antigen identified with proteomic analysis in prostate cancer
    J Cell Mol Med. 27 Jul. [Epub ahead of print].
  8. Kostova, M.B. et al. (2018) PSA-alpha-2-macroglobulin complex is enzymatically active in the serum of patients with advanced prostate cancer and can degrade circulating peptide hormones.
    Prostate. 78 (11): 819-29.
  9. View The Latest Product References

Functional Assays

Protein Purification

Kallikrein 3
Entrez Gene
GO Terms
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0006508 proteolysis
GO:0016525 negative regulation of angiogenesis
View more products with PROSTATE SPECIFIC specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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