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Prealbumin

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Native Human Prealbumin thumbnail image 1
Native Human Prealbumin gallery image 1
Published customer image:
Native human prealbumin (7600-0604) used in a protein aggregation experiment.
Image caption:
Validation of the protein aggregation assay.
Representative images for the internalization and accumulation of in vitro generated transthyretin (TTR) aggregates in ADTs. TTR aggregates were generated by incubation of recombinant human TTR in acetate buffer (see “Methods”). ADTs were treated with native TTR or aggregated TTR, fixed at 0 h or overnight after 20-min incubation on ice and then stained with ProteoStat dye (red). The nuclei were stained with DAPI (blue). Bar: 20 μm.

From: Cheng S, Banerjee S, Daiello LA, Nakashima A, Jash S, Huang Z, Drake JD, Ernerudh J, Berg G, Padbury J, Saito S, Ott BR, Sharma S.
Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease.
Sci Rep. 2021 Aug 5;11(1):15934.
doi: 10.1038/s41598-021-95611-5..
This image is from an open access article distributed under terms of a Creative Commons Attribution License.

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Native Human Prealbumin

Product Type
Purified Protein
Specificity
Prealbumin

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Product Code Applications Pack Size List Price Your Price Qty
7600-0604
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Native human prealbumin, also known as transthyretin, is a homotetrameric serum and cerebrospinal fluid protein which acts as a carrier for the thyroid hormone thyroxine. Each monomer is a 127 amino acid polypeptide. Prealbumin is synthesised principally in the liver and choroid plexus from where it is secreted into the serum and cerebrospinal fluid respectively.

Target Species
Human
Product Form
Purified protein from human serum - lyophilized
Reconstitution
Reconstitute with 1.0 ml sterile PBS. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution.
Buffer Solution
0.02M Ammonium bicarbonate (NH4HCO3).
Preservative Stabilisers
None present
Purity
>96%

SDS-PAGE confirms prealbumin as the major component. Under certain conditions dimer and monomer subunits can be seen. Cellulose acetate electrophoresis shows one band only with a higher electrophoretic mobility than albumin.
Approx. Protein Concentrations
Total protein concentration 1.0 mg/ml after reconstitution.
Protein Molecular Weight
60 kDa (tetramer)
Regulatory
For research purposes only
Guarantee
Guaranteed until date of expiry. Please see product label.

Store at +4°C. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for Prealbumin

  1. Clement, C.C. et al. (2016) Autoimmune response to transthyretin in juvenile idiopathic arthritis.
    JCI Insight. 1 (2): e85633.
  2. Cheng, S. et al. (2021) Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease.
    Sci Rep. 11 (1): 15934.

Synonyms
Transthyretin
UniProt
P02766
Entrez Gene
TTR
GO Terms
GO:0005576 extracellular region
GO:0005179 hormone activity
GO:0005737 cytoplasm
GO:0006810 transport
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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