IL-11

Recombinant Human Interleukin-11

Product Type
Recombinant Protein
Specificity
IL-11

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PHP048
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Human Interleukin 11 is a potent lymphoid cell growth factor which stimulates the growth and survival of certain B cells and T cells. This product has an ED50 of 0.5ng/ml as determined in a proliferation assay using murine T1165 hybridoma cells.

Target Species
Human
Product Form
Purified recombinant protein - lyophilized
Reconstitution
Reconstitute with 20ul distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution.
Preservative Stabilisers
None present
Carrier Free
Yes
Purity
>98% by SDS PAGE
Approx. Protein Concentrations
0.5 mg/ml after reconstitution
Protein Molecular Weight
19.5kDa (179 Amino acid sequence)
Regulatory
For research purposes only
Guarantee
Guaranteed for 3 months from the date of reconstitution or until the date of expiry, whichever comes first. Please see label for expiry date.

Prior to reconstitution store at -20oC. Following reconstitution store at -20oC. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Functional Assays 0.1ng/ml 10ng/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

UniProt
P20809
Entrez Gene
IL11
GO Terms
GO:0005125 cytokine activity
GO:0005142 interleukin-11 receptor binding
GO:0005615 extracellular space
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell proliferation
GO:0030168 platelet activation
GO:0030183 B cell differentiation
GO:0030219 megakaryocyte differentiation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043410 positive regulation of MAPKKK cascade
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046888 negative regulation of hormone secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
View more products with IL-11 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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