Beta 2 Microglobulin

Purified Human Beta 2 Microglobulin

Product Type
Purified Protein
Specificity
Beta 2 Microglobulin

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PHP135
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native beta-2 microglobulin is a component of MHC class I molecules, which are present on all nucleated cells. Levels of beta-2 microglobulin can be used to assess renal function in kidney transplant recipients. Also known as B2M, it has been suggested that this protein can be used as a prognostic marker for HIV infection.

Target Species
Human
Product Form
Human beta -2 microglobulin - lyophilized
Reconstitution
Reconstitute with 1.0ml sterile PBS
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution.
Preparation
Human beta-2 microglobulin was prepared from urine from patients with renal tubular proteinuria.
Buffer Solution
Ammonium bicarbonate
Preservative Stabilisers
None present
Purity
>98% by SDS-PAGE
Protein Molecular Weight
12 kDa
Regulatory
For research purposes only
Guarantee
Guaranteed for 3 months from the date of reconstitution or until the date of expiry, whichever comes first. Please see label for expiry date.

Store at +4oC. DO NOT FREEZE.
Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for Beta 2 Microglobulin

  1. Miles, J.J. et al. (2018) Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.
    J Clin Invest. 128 (4): 1569-80.

UniProt
P61769
Entrez Gene
B2M
GO Terms
GO:0000139 Golgi membrane
GO:0005515 protein binding
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0042612 MHC class I protein complex
GO:0006955 immune response
GO:0016032 viral reproduction
GO:0031901 early endosome membrane
GO:0050690 regulation of defense response to virus by virus
GO:0060333 interferon-gamma-mediated signaling pathway