Purified Human alpha fetoprotein is a 63 kDa protein which binds copper, nickel, fatty acids, bilirubin and serum albumin. It is expressed mostly during fetal development, existing only at very low levels in healthy adults. Alpha fetoprotein is therefore a useful marker for diseases such as hepatocellular carcinoma, testicular cancer, Downs syndrome and neural tube defects.
- Target Species
- Product Form
- Purified human alpha fetoprotein - liquid
- Purified human alpha fetoprotein from human cord serum
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Approx. Protein Concentrations
- Total protein concentration 1.0 mg/ml
- Protein Molecular Weight
- 63 kDa
- Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- Shelf Life
- 12 months from date of despatch
- P02771 Related reagents
- Entrez Gene
- AFP Related reagents
- GO Terms
- GO:0046872 metal ion binding
- GO:0006810 transport
- For research purposes only
Applications of Alpha Fetoprotein
|Application Name||Verified||Min Dilution||Max Dilution|
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Product Specific References
References for Alpha Fetoprotein
Mizejewski G. (2001) Alpha-fetoprotein Structure and Function: Relevance to Isoforms, Epitopes, and Conformational Variants.
Experimental Biology and Medicine, 226:377-408.
Hung, T.M. et al. (2011) Downregulation of alpha-fetoprotein expression by LHX4: a critical role in hepatocarcinogenesis.
Carcinogenesis. 32 (12): 1815-23.