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Alpha Fetoprotein

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Purified Human Alpha Fetoprotein

Product Type
Purified Protein
Specificity
Alpha Fetoprotein

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PHP152
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Purified Human alpha fetoprotein is a 63 kDa protein which binds copper, nickel, fatty acids, bilirubin and serum albumin. It is expressed mostly during fetal development, existing only at very low levels in healthy adults. Alpha fetoprotein is therefore a useful marker for diseases such as hepatocellular carcinoma, testicular cancer, Downs syndrome and neural tube defects.

Target Species
Human
Product Form
Purified human alpha fetoprotein - liquid
Preparation
Purified human alpha fetoprotein from human cord serum
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Purity
>95%.
Approx. Protein Concentrations
Total protein concentration 1.0 mg/ml
Protein Molecular Weight
63 kDa
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunoassay
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for Alpha Fetoprotein

  1. Mizejewski G. (2001) Alpha-fetoprotein Structure and Function: Relevance to Isoforms, Epitopes, and Conformational Variants.
    Experimental Biology and Medicine, 226:377-408.
  2. Hung, T.M. et al. (2011) Downregulation of alpha-fetoprotein expression by LHX4: a critical role in hepatocarcinogenesis.
    Carcinogenesis. 32 (12): 1815-23.

Synonyms
AFP
UniProt
P02771
Entrez Gene
AFP
GO Terms
GO:0046872 metal ion binding
GO:0006810 transport

PHP152

151844 156088 157060 163419

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