CXCL10 antibody | D03-4F4
Mouse anti Human CXCL10:Biotin
- Product Type
- Monoclonal Antibody
- Clone
- D03-4F4
- Isotype
- IgG1
- Specificity
- CXCL10
| Mouse anti Human CXCL10 antibody, clone D03-4F4, recognizes Chemokine C-X-C ligand 10 (CXCL10), also known as interferon-γ-inducible protein 10 (IP-10), is a member of the C-X-C subfamily of chemokines.
CXCL10 can be secreted by leukocytes, neutrophils, monocytes, endothelial cells, fibroblasts, thyrocytes and keratinocytes. CXCL10 plays a role in the recruitment of immune cells expressing its specific receptor, CXCR3. Beyond regulating immune cell migration, CXCL10 also plays a role in regulating cell growth and angiogenesis inhibition during tissue injury, development and maintenance.
Under normal physiological conditions, CXCL10 is usually undetectable in most non-lymphoid tissues. Only upon induction of an immunoinflammatory response through infection or injury is CXCL10 then detected (Muller et al. 2010). As such, CXCL10 has been used as a biomarker of disease severity and as a prognostic indicator for various renal diseases (Gao et al. 2020). This biotinylated Mouse anti Human CXCL10 antibody, clone D03-4F4 (MCA6189B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CXCL10 antibody, clone A01-2G1 (MCA6188GA) as the capture antibody. |
- Target Species
- Human
- Product Form
- Purified IgG conjugated to Biotin - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin - Immunogen
- E. coli derived recombinant human full length CXCL10 (Val22-Pro98)
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- ELISA Matched Pair(s)
-
ELISA Matched Pair-Capture Antibody:
MCA6188GA
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human CXCL10 | MCA6188GA | E | 0.1 mg |
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| Description | Mouse anti Human CXCL10 | ||||||
- Synonyms
- IP-10
- UniProt
- P02778
- Entrez Gene
- CXCL10
- GO Terms
- GO:0005615 extracellular space
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0007166 cell surface receptor linked signaling pathway
- GO:0007267 cell-cell signaling
- GO:0007517 muscle organ development
- GO:0008009 chemokine activity
- GO:0008015 blood circulation
- GO:0008284 positive regulation of cell proliferation
- View More GO Terms
- GO:0008603 cAMP-dependent protein kinase regulator activity
MCA6189B
100005233
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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