Syk antibody
In epithelial cells SYK appears to function as a negative regulator of related events. Furthermore, SYK has been shown to promote expression or secretion of inflammation-related molecules in lung epithelial cells.
SYK appears to be required for vascular integrity during development, thus, manipulation of SYK function in endothelial cells could potentially modulate tumour-associated angiogenesis. SYK also has been shown to interact with Epstein-Barr virus LMP2A.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Dog Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to SYK were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
0.02% Sodium Azide (NaN3) 0.5% Bovine Serum Albumin - Immunogen
- Peptide with sequence C-KYLQQNRHVKDKN from the internal region of the SYK sequence.
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P43405
- Entrez Gene
- SYK
- GO Terms
- GO:0005829 cytosol
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005178 integrin binding
- GO:0005524 ATP binding
- GO:0006461 protein complex assembly
- GO:0007159 leukocyte cell-cell adhesion
- GO:0007229 integrin-mediated signaling pathway
- GO:0009887 organ morphogenesis
- GO:0008283 cell proliferation
- GO:0030168 platelet activation
- GO:0030593 neutrophil chemotaxis
- GO:0042101 T cell receptor complex
- GO:0044419 interspecies interaction between organisms
- Regulatory
- For research purposes only
Applications of Syk antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | 1/16000 | ||
Western Blotting | 1.0 | 3.0ug/ml |
- Western Blotting
- AHP1066 detects a band of approximately 70kDa in human bone marrow, lymph node and spleen lysates.
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Rabbit anti Goat IgG (Fc):FITC | STAR122F | F | 1 mg |
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Rabbit anti Goat IgG (Fc):HRP | STAR122P | C E WB | 1 mg |
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Product Specific References
References for Syk antibody
-
Coopman, P.J. & Mueller, S.C. (2006) The Syk tyrosine kinase: a new negative regulator in tumor growth and progression.
Cancer Lett. 241 (2): 159-73. -
Wong, B.R. et al. (2004) Targeting Syk as a treatment for allergic and autoimmune disorders.
Expert Opin Investig Drugs. 13 (7): 743-62.
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