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Goat anti Scrib
- Product Type
- Polyclonal Antibody
- Polyclonal IgG
|Goat anti Human SCRIB antibody recognizes protein scribble homolog, also known as Scribble, CRIB1, KIAA0147, LAP4, SCRB1, and VARTUL.
SCRIB is a scaffold protein responsible for correct apical-basal cell polarity of the epithelial tissues (Kapil et al.. 2017). Appropriate polarity is important for cell migration and morphogenesis during development, and for wound healing in adult tissue. SCRIB also plays an important role in preventing cancer progression. Loss of SCRIB function disrupts apical-basal polarity and junctional integrity, and causes inappropriate proliferation which results in overgrowth of tissues. Overexpression of SCRIB has been found in tumors of the colon, breast, lung, ovary and prostate (Ono et al.. 2015). Correct SCRIB function depends on its localization to the plasma membrane, with mislocalization promoting invasion of cells through the extracellular matrix (Sun et al.. 2017). Accordingly, SCRIB can be found in the cytoplasm in some tumor types, and even in the nucleus in hepatocellular carcinoma and liver tumors (Kapil et al.. 2017). In Drosophila, SCRIB has been found to orchestrate an intracellular signaling process for forgetting information (Cervantes-Sandoval et al.. 2016).
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human SCRIB were raised by repeated immunizations of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
0.5% Bovine Serum Albumin
- Peptide with sequence C-PEGPGKEKELPGQ, from the internal region of the protein sequence according to NP_874365.3; NP_056171.3.
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- For research purposes only
- 12 months from date of despatch
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
|Application Name||Verified||Min Dilution||Max Dilution|
|Western Blotting||3 µg/ml||0.5 µg/ml|
- Western Blotting
- Goat anti Human SCRIB antibody detects a band of approximately 200 to 250 kDa in cell lysates.
|Description||Product Code||Applications||Pack Size||List Price||Your Price||Quantity|
|Rabbit anti Goat IgG (Fc):FITC||STAR122F||F||1 mg||Log in|
|List Price||Your Price|
|Description||Rabbit anti Goat IgG (Fc):FITC|
|Rabbit anti Goat IgG (Fc):HRP||STAR122P||C E WB||1 mg||Log in|
|List Price||Your Price|
|Description||Rabbit anti Goat IgG (Fc):HRP|
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