MMP-7 antibody

Goat anti Human MMP-7

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
MMP-7

Product Code Applications Pack Size List Price Your Price Qty
AHP1081
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E WB 0.1 mg
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Goat anti Huma MMP7 antibody recognises matrix metalloproteinase 7 (MMP7), a ~30 kDa member of the MMP family. MMP's are secreted as inactive zymogens which are activated when proteolytically cleaved by extracellular proteinases. They are involved in processes such as embryonic development, reproduction and tissue remodelling where they breakdown the extracellular matrix. This action is also exploited by diseases processes including arthritis and metastasis. MMP7 degrades casein, fibronectin, gelatin types I, III, IV, V, and activates procollagenase. This metalloproteinase has been identified as an activator of the Notch signalling pathway, and is also involved in wound healing and the regulation of defensins in intestinal mucosa.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human MMP7 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
0.02%Sodium Azide
0.5%Bovine Serum Albumin
Immunogen
Peptide sequence C-QKLYGKRSNSRKK corresponding to the C-terminus of MMP7 (NP_002414.1).
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/64000
Western Blotting 0.03 0.1ug/ml
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1081 detects a band of approximately 28kDa in human breast, ovary and placenta cell lysates. A minimum incubation time of 1 hour is recommended with this antibody.

Description Product Code Applications Pack Size List Price Your Price Quantity
Rabbit anti Goat IgG (Fc):FITC STAR122F F 1 mg loader
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loader
Description Rabbit anti Goat IgG (Fc):FITC
Rabbit anti Goat IgG (Fc):HRP STAR122P C E WB 1 mg loader
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loader
Description Rabbit anti Goat IgG (Fc):HRP

Further Reading

  1. Gaire, M. et al. (1994) Structure and expression of the human gene for the matrix metalloproteinase matrilysin.
    J Biol Chem. 269 (3): 2032-40.

Synonyms
Matrilysin
RRID
AB_2144333
UniProt
P09237
Entrez Gene
MMP7
GO Terms
GO:0004222 metalloendopeptidase activity
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0008270 zinc ion binding
GO:0030574 collagen catabolic process
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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