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IL-21 antibody

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Anti Human Interleukin-21 Antibody thumbnail image 1
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Staining of formalin fixed, paraffin embedded human spleen with Rabbit anti Human interleukin-21 (AHP1845).

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Rabbit anti Human Interleukin-21

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
IL-21

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Technical Suppport
Product Code Applications Pack Size List Price Your Price Qty
AHP1845
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P * WB 50 µg loader
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Rabbit anti Human interleukin-21 antibody recognizes human Interleukin-21 (IL-21), also known as Za11. IL-21 is a cytokine with immunoregulatory activity. IL-21 stimulates B- and T-cell proliferation and increases the activity of NK cells and disease-specific cytotoxic T-cells. It might also inhibit dendritic cell activation and maturation during the T-cell mediated immune response.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human IL-21 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
A synthetic peptide corresponding to 15 amino acids from near the centre of human IL-21 precursor.
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1 5ug/ml
Western Blotting 0.5 1.0ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human spleen

Description Product Code Applications Pack Size List Price Your Price Quantity
Antigen Retrieval Buffer, pH8.0 BUF025A P 500 ml
List Price Your Price
Description Antigen Retrieval Buffer, pH8.0
TidyBlot Western Blot Detection Reagent:HRP STAR209P WB* 0.5 ml
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Description TidyBlot Western Blot Detection Reagent:HRP

References for IL-21 antibody

  1. Tripodo, C. et al. (2010) Mast Cells and Th17 Cells Contribute to the Lymphoma-Associated Pro-Inflammatory Microenvironment of Angioimmunoblastic T-Cell Lymphoma.
    Am J Pathol. 177: 792-802.
  2. Coit, P. et al. (2016) DNA methylation analysis of the temporal artery microenvironment in giant cell arteritis.
    Ann Rheum Dis. 75 (6): 1196-202.

RRID
AB_2125266
UniProt
Q9HBE4
Entrez Gene
IL21
GO Terms
GO:0007165 signal transduction
GO:0005125 cytokine activity
GO:0005134 interleukin-2 receptor binding
GO:0005615 extracellular space
GO:0006955 immune response
GO:0032740 positive regulation of interleukin-17 production
GO:0034105 positive regulation of tissue remodeling
GO:0042102 positive regulation of T cell proliferation
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0048469 cell maturation
GO:0050729 positive regulation of inflammatory response
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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