FOXP2 antibody

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Goat anti Human FOXP2 (C-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP2020 E WB 0.1 mg
Goat anti Human FOXP2 antibody recognizes Forkhead box protein P2, also known as FOXP2, CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein. FOXP2 is a 715 amino acid ~80 kDa nuclear transcriptional repressor with a role in brain and lung development.

Mutations in the FOXP2 gene has been identified Speech-language disorder 1 (SPCH1), a disorder characterized by severe orofacial dyspraxia with speech impairment (Lai et al. 2001).

Multiple potential isoforms of FOXP2 generated by alternative splicing have been described. Goat anti Human FOXP2 antibody (AHP2020) is expected to recognize the canonical isoform 1 and also isoforms 3 and 9. However the antibody is not expected other isoforms which lack the c-terminal region (UniProt : 015409).

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mammals Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human FOXP2 (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin
Immunogen
Peptide with sequence C-REIEEEPLSEDLE from the C Terminus of FOXP2.
Approx. Protein Concentrations
IgG concentration 0.5mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
O15409 Related reagents
Entrez Gene
FOXP2 Related reagents
Regulatory
For research purposes only

Applications of FOXP2 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/32000
Western Blotting 0.5 1.5ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP2020 detects a band of approximately 80kDa in human cerebellum cell lysates.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Rabbit anti Goat IgG (Fc):FITC STAR122F 1 mg F
Rabbit anti Goat IgG (Fc):HRP STAR122P 1 mg C E WB

Product Specific References

References for FOXP2 antibody

  1. Vernes, S.C. et al. (2007) High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders.
    Am J Hum Genet. 81 (6): 1232-50.
  2. Vernes, S.C. et al. (2006) Functional genetic analysis of mutations implicated in a human speech and language disorder.
    Hum Mol Genet. 15 (21): 3154-67.