FHL1 antibody


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WB P ResetGoat anti Human FHL1
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- FHL1
Goat anti Human FHL1 antibody recognizes human Four and a half LIM domains protein 1, also known as FHL1, Skeletal muscle LIM-protein 1 or SLIM-1. FHL1 is a 323 amino acid ~30 kDa cytoplasmic protein containing multiple LIM domains. FHL1 is abundantly expressed by skeletal muscle and has been linked with several muscular dystrophy-like muscle disorders, including Scapuloperoneal syndrome (Quinzii et al. 2008), X-linked severe early-onset reducing body myopathy (Schlessl et al. 2011), and X-linked myopathy with postural muscle atrophy (Windpassinger et al. 2008). Goat anti Human FHL1 antibody is expected to recognise FHL1 isoform 5 and isoform 2, the latter being implicated as a negative regulator of RBP J- mediated transcription (Liang et al. 2008). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Dog Expected from Sequence Mouse Rat Expected from Sequence Bovine Expected from Sequence Pig Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human FHL1 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline.
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin - Immunogen
- Synthetic peptide sequence CNKRFVFHNEQVY from the internal region of FHL1 (NP_001440.1; NP_001153171.1).
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
1/32000 | |
Immunohistology - Paraffin 1 | ![]() |
2.0 | 2.5ug/ml |
Western Blotting | ![]() |
0.05 | 0.3ug/ml |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
- Histology Positive Control Tissue
- Human testis.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Rabbit anti Goat IgG (Fc):FITC | STAR122F | F | 1 mg |
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Description | Rabbit anti Goat IgG (Fc):FITC | ||||||
Rabbit anti Goat IgG (Fc):HRP | STAR122P | C E WB | 1 mg |
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Description | Rabbit anti Goat IgG (Fc):HRP |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | Log in | |||
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Description | Antigen Retrieval Buffer, pH8.0 |
References for FHL1 antibody
-
Emmanuele, V. et al. (2015) Fhl1 W122S causes loss of protein function and late-onset mild myopathy.
Hum Mol Genet. 24 (3): 714-26. -
Can, T. et al. (2014) Proteomic analysis of laser capture microscopy purified myotendinous junction regions from muscle sections.
Proteome Sci. 12: 25.
- Synonyms
- SLIM1
- RRID
- AB_2104218
- UniProt
- Q13642
- Entrez Gene
- FHL1
AHP2070


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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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