EIF2AK2 antibody

Rabbit anti EIF2AK2

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
EIF2AK2

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VPA00936
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Rabbit anti Human EIF2AK2 antibody recognizes EIF2AK2, also known as P1/eIF-2A protein kinase, double stranded RNA activated protein kinase, eIF-2A protein kinase 2, interferon-induced double-stranded RNA-activated protein kinase, interferon-inducible elF2alpha kinase and tyrosine-protein kinase EIF2AK2.

The protein encoded by EIF2AK2 is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for EIF2AK2 (provided by RefSeq, Oct 2011).

Rabbit anti Human EIF2AK2 detects a band of 74 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti EIF2AK2 antibody recognizes a band of approximately 74 kDa in HeLa cell lysates
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on immunogen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
<50% Glycerol
Immunogen
Recombinant protein of human EIF2AK2
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P19525
Entrez Gene
EIF2AK2
GO Terms
GO:0005515 protein binding
GO:0003725 double-stranded RNA binding
GO:0009615 response to virus
GO:0005829 cytosol
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005524 ATP binding
GO:0008601 protein phosphatase type 2A regulator activity
GO:0019054 modulation by virus of host cellular process
GO:0019058 viral infectious cycle
GO:0030683 evasion by virus of host immune response
GO:0033689 negative regulation of osteoblast proliferation
GO:0046777 protein autophosphorylation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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