Clusterin antibody
Goat anti Human Clusterin (C-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Clusterin
- Region
- (C-TERMINAL)
Antibody Quality and Performance Guarantee
| Goat anti Human clusterin antibody recognizes an epitope within the C-terminal (CT) region of human clusterin, otherwise known as Apolipoprotein J, a ubiquitously expressed glycoprotein and member of the clusterin family, implicated in apoptosis (programmed cell death), cell-cell adhesion, DNA repair, membrane recycling, spermatogenesis, and the inhibition of complement-mediated cell lysis. Clusterin is a component of the SC5b-9 complex which plays a role in inhibiting the complement cascade, through the prevention of the binding of a C5b-C7 complex to the membrane of the target cell. Clusterin exists as both a pro-apoptotic form localised to the nucleus, and a pro-survival secreted form, and has been detected at elevated levels in Alzheimer’s disease, atherosclerosis, myocardial infarction, and various cancers, including bladder, prostate, and breast tumours. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Dog Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human clusterin (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin - Immunogen
- Synthetic peptide sequence C-EKALQEYRKKHREE from the C-Terminal region of clusterin (NP_001822.2; NP_976084.1).
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1/32000 | |
| Western Blotting | |
0.3 | 1.0ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- AHP2129 detects a band of approximately 35-37kDa in human colon, kidney and prostate cell lysates.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Rabbit anti Goat IgG (Fc):FITC | STAR122F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Rabbit anti Goat IgG (Fc):FITC | ||||||
| Rabbit anti Goat IgG (Fc):HRP | STAR122P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Rabbit anti Goat IgG (Fc):HRP | ||||||
- Synonyms
- Apolipoprotein J
- RRID
- AB_2083460
- UniProt
- P10909
- Entrez Gene
- CLU
- GO Terms
- GO:0001836 release of cytochrome c from mitochondria
- GO:0002576 platelet degranulation
- GO:0009615 response to virus
- GO:0005739 mitochondrion
- GO:0006629 lipid metabolic process
- GO:0006958 complement activation, classical pathway
- GO:0051787 misfolded protein binding
- GO:0030168 platelet activation
- GO:0031093 platelet alpha granule lumen
- View More GO Terms
- GO:0032463 negative regulation of protein homooligomerization
- GO:0034366 spherical high-density lipoprotein particle
- GO:0043691 reverse cholesterol transport
- GO:0045087 innate immune response
- GO:0051788 response to misfolded protein
AHP2129
160824
161011
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
View more products with CLUSTERIN specificity
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