Caveolin 1 antibody
Rabbit anti Human caveolin 1 antibody recognizes caveolin-1 also known as cell growth-inhibiting protein 32, CAV1, or PPH3 .
The scaffolding protein encoded by CAV1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in CAV1 have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1 (provided by RefSeq, Mar 2010).
Rabbit anti Human caveolin 1 antibody detects a band of 21 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The scaffolding protein encoded by CAV1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in CAV1 have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1 (provided by RefSeq, Mar 2010).
Rabbit anti Human caveolin 1 antibody detects a band of 21 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Rabbit anti caveolin 1 detects a band of approximately 21 kDa in A549 cell lysates
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.01% Thiomersal
1% Bovine Serum Albumin
<50% Glycerol - Immunogen
- Carrier-protein conjugated synthetic peptide encompassing part of the N-terminal region of human caveolin 1
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q03135
- Entrez Gene
- CAV1
- GO Terms
- GO:0000139 Golgi membrane
- GO:0000188 inactivation of MAPK activity
- GO:0005515 protein binding
- GO:0001570 vasculogenesis
- GO:0001666 response to hypoxia
- GO:0001937 negative regulation of endothelial cell proliferation
- GO:0007596 blood coagulation
- GO:0005102 receptor binding
- GO:0005783 endoplasmic reticulum
- GO:0005811 lipid particle
- GO:0005901 caveola
- GO:0006641 triglyceride metabolic process
- GO:0006816 calcium ion transport
- GO:0006940 regulation of smooth muscle contraction
- GO:0007519 skeletal muscle tissue development
- GO:0009267 cellular response to starvation
- GO:0010524 positive regulation of calcium ion transport into cytosol
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0015485 cholesterol binding
- GO:0016050 vesicle organization
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0016504 peptidase activator activity
- GO:0019217 regulation of fatty acid metabolic process
- GO:0019915 lipid storage
- GO:0030193 regulation of blood coagulation
- GO:0030514 negative regulation of BMP signaling pathway
- GO:0030857 negative regulation of epithelial cell differentiation
- GO:0031295 T cell costimulation
- GO:0031623 receptor internalization
- GO:0032091 negative regulation of protein binding
- GO:0032507 maintenance of protein location in cell
- GO:0032570 response to progesterone stimulus
- GO:0032947 protein complex scaffold
- GO:0033137 negative regulation of peptidyl-serine phosphorylation
- GO:0033138 positive regulation of peptidyl-serine phosphorylation
- GO:0033484 nitric oxide homeostasis
- GO:0042632 cholesterol homeostasis
- GO:0051260 protein homooligomerization
- GO:0043409 negative regulation of MAPKKK cascade
- GO:0043627 response to estrogen stimulus
- GO:0044419 interspecies interaction between organisms
- GO:0045019 negative regulation of nitric oxide biosynthetic process
- GO:0045907 positive regulation of vasoconstriction
- GO:0046209 nitric oxide metabolic process
- GO:0048471 perinuclear region of cytoplasm
- GO:0048554 positive regulation of metalloenzyme activity
- GO:0050900 leukocyte migration
- GO:0050998 nitric-oxide synthase binding
- GO:0050999 regulation of nitric-oxide synthase activity
- GO:0051480 cytosolic calcium ion homeostasis
- GO:0051592 response to calcium ion
- GO:0051899 membrane depolarization
- GO:0060056 mammary gland involution
- GO:0070836 caveola assembly
- GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
- GO:0090263 positive regulation of canonical Wnt receptor signaling pathway
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of Caveolin 1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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