Rabbit anti Human caspase-10 antibody recognizes caspase-10, also known as CASP-10, FADD-like ICE2, FAS-associated death domain protein interleukin-1B-converting enzyme 2, ICE-like apoptotic protease 4, apoptotic protease MCH-4, apoptosis-related cysteine protease or interleukin-1B-converting enzyme 2.

CASP10 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in CASP10 are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for CASP10 (provided by RefSeq, Apr 2011).

Rabbit anti Human caspase-10 antibody detects a band of 58 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000