ABCB5 antibody

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WB ResetGoat anti Human ABCB5
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- ABCB5
Goat anti Human ABCB5 antibody recognises human ABCB5 (ATP-binding cassette sub-family B member 5), a P-glycoprotein and member of the conserved ABC transporter family, which acts as an energy-dependent efflux transporter for rhodamine (Frank et al. 2003). ABCB5 is primarily expressed by skin progenitor cells and acts as a regulator of cell fusion and determinant of membrane potential. ABCB5 is expressed in human malignant melanoma, and is associated with CD133+ stem cell phenotype-expressing cells. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to ABCB5 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin - Immunogen
- Peptide sequence C-QTQHRNTSKKAQ from the internal region of ABCB5 (NP_848654.3)
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
1/128000 | |
Western Blotting | ![]() |
0.03 | 0.1ug/ml |
- Western Blotting
- AHP1667 detects a band of approximately 80kDa in A431cell lysates
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Rabbit anti Goat IgG (Fc):FITC | STAR122F | F | 1 mg |
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Description | Rabbit anti Goat IgG (Fc):FITC | ||||||
Rabbit anti Goat IgG (Fc):HRP | STAR122P | C E WB | 1 mg |
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Description | Rabbit anti Goat IgG (Fc):HRP |
References for ABCB5 antibody
-
Parmakhtiar, B. et al. (2019) HIF Inactivation of p53 in Ovarian Cancer Can Be Reversed by Topotecan, Restoring Cisplatin and Paclitaxel Sensitivity.
Mol Cancer Res. 17 (8): 1675-86.
Further Reading
-
Moitra, K. et al. (2011) Molecular evolutionary analysis of ABCB5: the ancestral gene is a full transporter with potentially deleterious single nucleotide polymorphisms.
PLoS One. 6: e16318.
- RRID
- AB_2220822
- UniProt
- Q2M3G0
- Entrez Gene
- ABCB5
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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