CD8 antibody | YTS169.4
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Rat anti Mouse CD8:Alexa Fluor® 647
- Product Type
- Monoclonal Antibody
|Rat anti Mouse CD8 antibody, clone YTS169.4 recognizes the murine CD8 cell surface antigen, expressed by a subset of T lymphocytes.
Rat anti Mouse CD8 antibody, clone YTS169.4 exhibits depleting activity when used in vivo.
- Target Species
- Product Form
- Purified IgG conjugated to Alexa Fluor® 647 - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
1% bovine serum albumin
- Approx. Protein Concentrations
- IgG concentration 0.05 mg/ml
- Max Ex/Em
Fluorophore Excitation Max (nm) Emission Max (nm) Alexa Fluor®647 650 665
- For research purposes only
- 12 months from date of despatch
- This product is provided under an intellectual property licence from Life Technologies Corporation. The transfer of this product is contingent on the buyer using the purchase product solely in research, excluding contract research or any fee for service research, and the buyer must not sell or otherwise transfer this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; (c) manufacturing or quality assurance or quality control, or (d) resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad CA 92008 USA or firstname.lastname@example.org
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
|Application Name||Verified||Min Dilution||Max Dilution|
References for CD8 antibody
Cobbold, S.P. et al. (1984) Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo.
Nature. 312 (5994): 548-51.
Cobbold, S.P. et al. (1990) The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies.
Eur J Immunol. 20 (12): 2747-55.
Wise, M.P. et al. (1998) Linked suppression of skin graft rejection can operate through indirect recognition.
J Immunol. 161 (11): 5813-6.
Bemelman, F. et al. (1998) Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.
J Immunol. 160 (6): 2645-8.
Higgins, L.M. et al. (1999) Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein.
J Immunol. 162 (1): 486-93.
Jaffar, Z. et al. (2002) A key role for prostaglandin I2 in limiting lung mucosal Th2, but not Th1, responses to inhaled allergen.
J Immunol. 169 (10): 5997-6004.
Scotland, R.S. et al. (2011) Sex-differences in resident immune cell phenotype underlies more efficient acute inflammatory responses in female mice.
Blood. 118: 5918-27.
Zirger, J.M. et al. (2012) Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells.
Mol Ther. 20 (4): 808-19.
View The Latest Product References
Abd-elhakim, Y.M. et al. (2016) Hemato-immunologic impact of subchronic exposure to melamine and/or formaldehyde in mice.
J Immunotoxicol. 13 (5): 713-22.
Matsubara, K. et al. (2016) Immune activation during the implantation phase causes preeclampsia-like symptoms via the CD40-CD40 ligand pathway in pregnant mice.
Hypertens Res. 39 (6): 407-14.
de Souza, T.A. et al. (2018) Relationship between the inflammatory tumor microenvironment and different histologic types of canine mammary tumors.
Res Vet Sci. 119: 209-14.
Nelvagal, H.R. et al. (2020) Comparative proteomic profiling reveals mechanisms for early spinal cord vulnerability in CLN1 disease.
Sci Rep. 10 (1): 15157.
Lejeune, P. et al. (2021) Immunostimulatory effects of targeted thorium-227 conjugates as single agent and in combination with anti-PD-L1 therapy.
J Immunother Cancer. (10):e002387.
- Entrez Gene
- GO Terms
- GO:0002456 T cell mediated immunity
- GO:0016021 integral to membrane
- GO:0007166 cell surface receptor linked signaling pathway
- GO:0009897 external side of plasma membrane
- GO:0042803 protein homodimerization activity
- GO:0045065 cytotoxic T cell differentiation
- GO:0050850 positive regulation of calcium-mediated signaling
- GO:0005515 protein binding
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