CD41 antibody | MWReg30
Rat anti Mouse CD41:StarBright Blue 700
- Product Type
- Monoclonal Antibody
- Clone
- MWReg30
- Isotype
- IgG1
- Specificity
- CD41
Rat anti Mouse CD41 antibody, clone MWReg30 recognizes the mouse integrin alpha IIb subunit CD41. CD41 is a ~125 kDa single pass type 1 transmembrane glycoprotein expressed by platelets, megakaryocytes (Zhang et al. 2007), mast cells (Berlanga et al. 2005), and hematopoietic progenitors (Mitjavila-Garcia et al. 2002). CD41 forms a heterodimer with CD61. The CD41/CD61 complex is important for platelet adhesion and aggregation (Patel et al. 2003) acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin (Weisel et al. 1992). Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al. 1999). |
- Target Species
- Mouse
- Product Form
- Purified IgG conjugated to StarBright Blue 700 - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
0.1% Pluronic F68
0.1% PEG 3350
0.05% Tween 20 - Immunogen
- Purified murine platelets
- Max Ex/Em
-
Fluorophore Excitation Max (nm) Emission Max (nm) StarBright Blue 700 473 703 - Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product is covered by U.S. Patent No. 10,150,841 and related U.S. and foreign counterparts
This product should be stored undiluted.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | Neat |
- Flow Cytometry
- Use 5μl of the suggested working dilution to label 106 cells in 100μl. Best practices suggest a 5 minutes centrifugation at 6,000g prior to sample application.
How to Use the Spectraviewer
Watch the Tool Tutorial Video ▸- Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
- Select the fluorophores or fluorescent proteins you want to include in your panel to check compatibility
- Select the lasers and filters you wish to include
- Select combined or multi-laser view to visualize the spectra
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Source Reference
-
Nieswandt, B. et al. (1999) Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.
Blood. 94 (2): 684-93.
References for CD41 antibody
-
Larson, M.K. and Watson, S.P. (2006) Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3.
Blood. 108: 1509-14. -
Tamagawa-Mineoka, R. et al. (2007) The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation.
Am J Pathol. 170: 2019-29. -
Lutskiy, M.I. et al. (2007) WASP localizes to the membrane skeleton of platelets.
Br J Haematol. 139: 98-105. -
Perez, L.E. et al. (2008) SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors.
PLoS One. 3: e3565. -
Zanzinger, K. et al. (2009) Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes.
Immunology. 128: 185-95. -
Winter, O. et al. (2010) Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.
Blood. 116: 1867-75. -
Takayama, M. et al. (2010) Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis.
Mol Cell Biol. 30: 2668-80. -
Sullivan, B.P. et al. (2010) Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.
Toxicol Sci. 115: 286-94.
View The Latest Product References
-
Motohashi, H. et al. (2010) NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.
Blood. 115 (3): 677-86. -
Göçmen, A.Y. et al. (2011) Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target.
Appl Physiol Nutr Metab. 36 (3): 323-30. -
Teeling, J.L. et al. (2012) Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction
Acta Neuropathol. 124: 479-90. -
Fujita, R. et al. (2013) NF-E2 p45 Is Important for Establishing Normal Function of Platelets.
Mol Cell Biol. 33: 2659-70. -
Goggs, R. et al. (2013) The small GTPase Rif is dispensable for platelet filopodia generation in mice.
PLoS One. 8 (1): e54663. -
Woods, S.J. et al. (2015) Kinetic profiling of in vivo lung cellular inflammatory responses to mechanical ventilation.
Am J Physiol Lung Cell Mol Physiol. 308 (9): L912-21. -
Flierl, U. et al. (2015) Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.
J Exp Med. 212 (2): 129-37. -
Devanathan, V. et al. (2015) Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice.
Proc Natl Acad Sci U S A. 112 (20): 6491-6. -
Cuccurullo, A. et al. (2016) Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis.
PLoS One. 11 (3): e0151088. -
Ryan, J. et al. (2016) Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase.
J Pathol. 238 (1): 10-20. -
Criel, M. et al. (2016) Absence of Pear1 does not affect murine platelet function in vivo.
Thromb Res. 146: 76-83. -
Asai, J. et al. (2016) Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice.
Am J Pathol. 186 (1): 101-8. -
Williams, C.M. et al. (2016) Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets.
Platelets. 27 (4): 286-94. -
Thomson, A.K. et al. (2017) Survival of motor neurone protein is required for normal postnatal development of the spleen.
J Anat. 230 (2): 337-46. -
Moore, S.F. et al. (2021) Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis.
Int J Mol Sci. 22(19):10656.
- Synonyms
- INTEGRIN ALPHA IIB
- UniProt
- Q9QUM0
- Entrez Gene
- Itga2b
- GO Terms
- GO:0004872 receptor activity
- GO:0008305 integrin complex
- GO:0005925 focal adhesion
- GO:0007160 cell-matrix adhesion
- GO:0007229 integrin-mediated signaling pathway
- GO:0009897 external side of plasma membrane
- GO:0050840 extracellular matrix binding
MCA2245SBB700
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