CD200 antibody | OX-90
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F BA IF C ResetRat anti Mouse CD200:RPE
- Product Type
- Monoclonal Antibody
- Clone
- OX-90
- Isotype
- IgG2a
- Specificity
- CD200
Rat anti Mouse CD200 antibody, clone OX-90 recognizes the mouse CD200 cell surface antigen, also known as OX2. CD200 is expressed by splenic B lymphocytes, follicular dendritic cells, splenic endothelium and by neurons. The CD200 - CD200 ligand system is of importance in the control of macrophage and granulocyte activation. |
- Target Species
- Mouse
- Product Form
- Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
- Reconstitution
- Reconstitute with 1ml distilled water
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
1% bovine serum albumin
5% sucrose - Immunogen
- Mouse CD200-rat CD4 fusion protein.
- Fusion Partners
- Spleen cells from immunised rats were fused with cells of the rat Y3 myeloma cell line
- Max Ex/Em
-
Fluorophore Excitation Max (nm) Emission Max (nm) RPE 488nm laser 496 578 - Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
DO NOT FREEZE.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry |
How to Use the Spectraviewer
Watch the Tool Tutorial Video ▸- Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
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Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Rat IgG2a Negative Control:RPE | MCA1212PE | F | 100 Tests | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Rat IgG2a Negative Control:RPE |
References for CD200 antibody
-
Hoek, R.M. et al. (2000) Down-regulation of the macrophage lineage through interaction with OX2 (CD200).
Science. 290 (5497): 1768-71. -
Nathan, C. & Muller, W.A. (2001) Putting the brakes on innate immunity: a regulatory role for CD200?
Nat Immunol. 2 (1): 17-9. -
Rijkers, E.S. (2007) Ligation of CD200R by CD200 is not required for normal murine myelopoiesis.
Eur J Haematol. 79: 410-6. -
Rijkers, E.S. et al. (2008) The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes.
Mol Immunol. 45: 1126-35. -
Burger, P.E. et al. (2009) High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells.
Stem Cells. 27: 2220-8. -
Ko, Y.C. et al (2009) Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions.
J Anat. 214: 183-95. -
Koning, N. et al. (2009) Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions.
J Neuropathol Exp Neurol. 68: 159-67. -
Seeds, R.E. et al. (2011) The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon.
Int Immunopharmacol. 11 (7): 794-801.
View The Latest Product References
-
Garza, L.A. et al. (2011) Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells.
J Clin Invest. 121: 613-22. -
Montiel, M. et al. (2015) Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus.
Antivir Chem Chemother. 24 (3-4): 99-108. -
Liu, J.Q. et al. (2016) A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.
J Immunol. 197 (4): 1489-97. -
Liu, C. et al. (2018) The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation.
J Inflamm (Lond). 15: 28. -
Lago, N. et al. (2018) CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1.
Brain Behav Immun. 73: 416-26. -
Tonecka, K. et al. (2021) The CD200 Regulates Inflammation in Mice Independently of TNF-α Production.
Int J Mol Sci. 22 (10): 5358. -
Pannunzio, B. et al. (2022) CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury
Cells. 11 (11): 1786.
- Synonyms
- OX2
- RRID
- AB_324640
- UniProt
- O54901
- Entrez Gene
- Cd200
- GO Terms
- GO:0005886 plasma membrane
- GO:0005515 protein binding
- GO:0016021 integral to membrane
MCA1958PE
158103If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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