PP1 Alpha antibody | OTI6E5

Mouse anti PP1 Alpha

Product Type
PrecisionAb Monoclonal
Clone
OTI6E5
Isotype
IgG1
Format
Purified
Specificity
PP1 Alpha

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VMA00742
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Mouse anti Human PP1 alpha antibody recognizes PP1 alpha, also known as protein phosphatase 1-alpha isoform and serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit.

The protein encoded by PPP1CA is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure and is an important regulator of cardiac function. PP1 also appears to function as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for PPP1CA (provided by RefSeq, Jul 2008).

Mouse anti Human PP1 alpha antibody detects a band of 38 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti PP1 alpha detects a band of approximately 38 kDa in Jurkat cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
Immunogen
E. coli-derived full length recombinant protein of human PP1 alpha
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P62136
Entrez Gene
PPP1CA
GO Terms
GO:0005515 protein binding
GO:0005829 cytosol
GO:0004722 protein serine/threonine phosphatase activity
GO:0046872 metal ion binding
GO:0005730 nucleolus
GO:0005977 glycogen metabolic process
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0008599 protein phosphatase type 1 regulator activity
GO:0019433 triglyceride catabolic process
GO:0051301 cell division
GO:0070688 MLL5-L complex
GO:0072357 PTW/PP1 phosphatase complex
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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