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MRE11 antibody | AB02/1D11

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Anti MRE11 Antibody, clone AB02/1D11 (PrecisionAb Monoclonal Antibody) thumbnail image 1 Anti MRE11 Antibody, clone AB02/1D11 (PrecisionAb Monoclonal Antibody) thumbnail image 2
Anti MRE11 Antibody, clone AB02/1D11 (PrecisionAb Monoclonal Antibody) gallery image 1
Western blot analysis of whole cell lysates probed with MRE11 antibody followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 118 second exposure. Arrow points to MRE11 (molecular weight 81 kDa)
Anti MRE11 Antibody, clone AB02/1D11 (PrecisionAb Monoclonal Antibody) gallery image 2
Immunoprecipitation of MRE11 from HEK293 whole cell lysate. The Input lane is 10% input; the MRE11-IP lane is the immunoprecipitation with the MRE11 antibody (2.5 µg, VMA00536); the IgG-IP lane is the immunoprecipitation with Mouse monoclonal IgG (2.5 µg, MCA928). Western blot analysis was performed using MRE11 antibody (1/1,000, VMA00536) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, 1705047) and visualized on the ChemiDoc MP. Arrow points to MRE11.

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WB IP

Mouse anti MRE11

Product Type
PrecisionAb Monoclonal
Clone
AB02/1D11
Isotype
IgG1
Format
Purified
Specificity
MRE11

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Product Code Applications Pack Size List Price Your Price Qty
VMA00536
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IP WB 100 µl loader
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Mouse anti Human MRE11 antibody recognizes the double-strand break repair protein MRE11A, also known as AT-like disease DNA recombination and repair protein, MRE11 homolog 1, MRE11 homolog A, endo/exonuclease Mre11 or meiotic recombination 11 homolog A.

MRE11A gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. MRE11A has a pseudogene on chromosome 3. Alternative splicing of MRE11A results in two transcript variants encoding different isoforms (provided by RefSeq, Jul 2008).

Mouse anti Human MRE11 antibody detects a band of 81 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.		 PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti MRE11 detects a band of approximately 81 kDa in HEK293 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
E. coli-derived recombinant human MRE11A (amino acids 182 - 582)
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P49959
Entrez Gene
MRE11A
GO Terms
GO:0000014 single-stranded DNA specific endodeoxyribonuclease activity
GO:0000019 regulation of mitotic recombination
GO:0000724 double-strand break repair via homologous recombination
GO:0003690 double-stranded DNA binding
GO:0005654 nucleoplasm
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0007004 telomere maintenance via telomerase
GO:0007062 sister chromatid cohesion
GO:0007131 reciprocal meiotic recombination
GO:0008022 protein C-terminus binding
GO:0008408 3'-5' exonuclease activity
GO:0030145 manganese ion binding
GO:0030870 Mre11 complex
GO:0031954 positive regulation of protein autophosphorylation
GO:0032508 DNA duplex unwinding
GO:0032876 negative regulation of DNA endoreduplication
GO:0033674 positive regulation of kinase activity

VMA00536

170420

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