IL6R antibody | rhPM-1

Human anti IL6R (Tocilizumab Biosimilar)

Product Type
Monoclonal Antibody
Clone
rhPM-1
Isotype
IgG1
Specificity
IL6R

Product Code Applications Pack Size List Price Your Price Qty
MCA6106
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SDS Safety Datasheet SDS
E 0.2 mg loader
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Human Anti-IL6R Antibody, clone rhPM-1 is a research grade biosimilar of the monoclonal antibody drug tocilizumab. It is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic antibody tocilizumab. This product is supplied in a research grade format, i.e. in PBS buffer with preservative, it is not manufactured or formulated in the same way as the therapeutic reference product. A preservative free version is available on request.

Human Anti-IL6R Antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-tocilizumab antibodies, for example HCA252 and HCA253P. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-tocilizumab antibody in IgG1 format as reference standard, for example HCA253.

Tocilizumab (Actemra/RoActemra) is a humanized IgG1/kappa monoclonal antibody approved for the treatment of moderate to severe rheumatoid arthritis and for the treatment of systemic juvenile idiopathic arthritis. The therapeutic antibody is directed against IL-6R and acts by blocking the binding of IL-6R (both the soluble form, sIL-6R, and the membrane bound form, mIL-6R) to IL-6, thus impeding the pro-inflammatory properties of this cytokine.

This product is NOT FOR THERAPEUTIC USE.

View a summary of supporting anti-tocilizumab antibody products.

Target Species
Human
Product Form
Human IgG1 (kappa) antibody - liquid
Preparation
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Proclin 300
Immunogen
Mouse AUK 12-20 antibody CDRs grafted onto human framework
Purity
>98% by SDS PAGE
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
A0N0L5
Licensed Use
For in vitro research purposes only. Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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