IL6R antibody | rhPM-1
|Human Anti-IL6R Antibody, clone rhPM-1 is a research grade biosimilar of the monoclonal antibody drug tocilizumab. It is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic antibody tocilizumab. This product is supplied in a research grade format, i.e. in PBS buffer with preservative, it is not manufactured or formulated in the same way as the therapeutic reference product. A preservative free version is available on request.
Human Anti-IL6R Antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-tocilizumab antibodies, for example HCA252 and HCA253P. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-tocilizumab antibody in IgG1 format as reference standard, for example HCA253.
Tocilizumab (Actemra/RoActemra) is a humanized IgG1/kappa monoclonal antibody approved for the treatment of moderate to severe rheumatoid arthritis and for the treatment of systemic juvenile idiopathic arthritis. The therapeutic antibody is directed against IL-6R and acts by blocking the binding of IL-6R (both the soluble form, sIL-6R, and the membrane bound form, mIL-6R) to IL-6, thus impeding the pro-inflammatory properties of this cytokine.
This product is NOT FOR THERAPEUTIC USE.
View a summary of supporting anti-tocilizumab antibody products.
- Target Species
- Product Form
- Human IgG1 (kappa) antibody - liquid
- Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Proclin 300
- Mouse AUK 12-20 antibody CDRs grafted onto human framework
- >98% by SDS PAGE
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Description||Product Code||Applications||Pack Size||List Price||Your Price||Quantity|
|Hispec Assay Diluent||BUF049A||E IY||50 ml||Log in|
|List Price||Your Price|
|Description||Hispec Assay Diluent|
|LYNX Rapid HRP Antibody Conjugation Kit||LNK002P||CJ||3 Conjugations For 400µg Antibody||Log in|
|List Price||Your Price|
|Description||LYNX Rapid HRP Antibody Conjugation Kit|
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