GLRX antibody | AB01/1D2

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Anti GLRX Antibody, clone AB01/1D2 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti GLRX Antibody, clone AB01/1D2 (PrecisionAb Monoclonal Antibody) thumbnail image 2

Anti GLRX Antibody, clone AB01/1D2 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with GLRX antibody (1/1,000, **VMA00805**) followed by detection with HRP conjugated Goat anti Mouse detection reagent (1/10,000, [1705047]) and visualized on the ChemiDoc MP. Arrow points to GLRX (molecular weight 11 kDa).

Anti GLRX Antibody, clone AB01/1D2 (PrecisionAb Monoclonal Antibody) gallery image 2 — Immunoprecipitation of GLRX from HepG2 whole cell lysate. The Input lane is 10% input; the GLRX-IP lane is the immunoprecipitation with the GLRX antibody (2.5 µg, **VMA00805**); the IgG-IP lane is the immunoprecipitation with Mouse monoclonal IgG (2.5 µg, MCA928). Western blot analysis was performed using GLRX antibody (1/1000, **VMA00805**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, 1705047) and visualized on the ChemiDoc MP. Arrow points to GLRX.

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WB IP

Mouse anti GLRX

Product Type: PrecisionAb Monoclonal
Clone: AB01/1D2
Isotype: IgG1
Format: Purified
Specificity: GLRX

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Product Code Applications Pack Size List Price Your Price Qty

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VMA00805 Datasheet Datasheet SDS SDS	IP WB	100 µl		Log in	Get Quote
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Mouse anti GLRX antibody recognizes glutaredoxin-1, also known as TTase-1 and GRX.

GLRX is a redox-regulator and is involved with cell survival through a number of mechanisms. The protein plays an important role in responses to oxidative stress, which is a significant risk factor for many diseases. GLRX fused to PEP-1 peptide has been shown to attenuate neuronal cell death that results from oxidative stress, and therefore, PEP-1-GLRX1 has been suggested as beneficial for treating neuronal disorders (Ryu et al. 2018). Exogenous GLRX may also have therapeutic potential in the treatment of idiopathic pulmonary fibrosis, also due to its role in oxidative stress (Anathy et al. 2018). Inhibition of GLRX enhances the effect of the tyrosine kinase inhibitor gefitinib in non-small-cell lung cancer calls that are resistant to this drug (Wang et al. 2019).

Target Species: Human
Western Blotting: Mouse anti xx antibody detects a band of approximately 11 kDa in HepG2 cell lysates
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse

Rat; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - Liquid
Preparation: Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide
Immunogen: E. coli-derived recombinant protein of amino acids 1-147 of human GLRX
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Target Species	Cross Reactivity
Mouse
Rat

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Immunoprecipitation
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: P35754
Entrez Gene: GLRX
GO Terms: GO:0009055 electron carrier activity; GO:0005829 cytosol; GO:0045454 cell redox homeostasis; GO:0022900 electron transport chain; GO:0006810 transport; GO:0015038 glutathione disulfide oxidoreductase activity; GO:0015035 protein disulfide oxidoreductase activity; GO:0015949 nucleobase, nucleoside and nucleotide interconversion; GO:0047485 protein N-terminus binding; View More GO Terms