GLRX antibody | AB01/1D2

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Mouse anti GLRX

Product Type
PrecisionAb Monoclonal
Clone
AB01/1D2
Isotype
IgG1
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00805
Datasheet
IP WB
SDS
100 µl loader

Mouse anti GLRX antibody recognizes glutaredoxin-1, also known as TTase-1 and GRX.

GLRX is a redox-regulator and is involved with cell survival through a number of mechanisms. The protein plays an important role in responses to oxidative stress, which is a significant risk factor for many diseases. GLRX fused to PEP-1 peptide has been shown to attenuate neuronal cell death that results from oxidative stress, and therefore, PEP-1-GLRX1 has been suggested as beneficial for treating neuronal disorders (Ryu et al. 2018). Exogenous GLRX may also have therapeutic potential in the treatment of idiopathic pulmonary fibrosis, also due to its role in oxidative stress (Anathy et al. 2018). Inhibition of GLRX enhances the effect of the tyrosine kinase inhibitor gefitinib in non-small-cell lung cancer calls that are resistant to this drug (Wang et al. 2019).

Product Details

Target Species
Human
Western Blotting
Mouse anti xx antibody detects a band of approximately 11 kDa in HepG2 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-147 of human GLRX
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
P35754
Entrez Gene
GLRX
GO Terms
GO:0009055 electron carrier activity
GO:0005829 cytosol
GO:0045454 cell redox homeostasis
GO:0022900 electron transport chain
GO:0006810 transport
GO:0015038 glutathione disulfide oxidoreductase activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0015949 nucleobase, nucleoside and nucleotide interconversion
GO:0047485 protein N-terminus binding
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of GLRX antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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