GLRX antibody | AB01/1D2
IP-MS Validated
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WB IP ResetMouse anti GLRX
- Product Type
- PrecisionAb Monoclonal
- Clone
- AB01/1D2
- Isotype
- IgG1
- Format
- Purified
- Specificity
- GLRX
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| Mouse anti GLRX antibody recognizes glutaredoxin-1, also known as TTase-1 and GRX. GLRX is a redox-regulator and is involved with cell survival through a number of mechanisms. The protein plays an important role in responses to oxidative stress, which is a significant risk factor for many diseases. GLRX fused to PEP-1 peptide has been shown to attenuate neuronal cell death that results from oxidative stress, and therefore, PEP-1-GLRX1 has been suggested as beneficial for treating neuronal disorders (Ryu et al. 2018). Exogenous GLRX may also have therapeutic potential in the treatment of idiopathic pulmonary fibrosis, also due to its role in oxidative stress (Anathy et al. 2018). Inhibition of GLRX enhances the effect of the tyrosine kinase inhibitor gefitinib in non-small-cell lung cancer calls that are resistant to this drug (Wang et al. 2019). |
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- Target Species
- Human
- Western Blotting
- Mouse anti xx antibody detects a band of approximately 11 kDa in HepG2 cell lysates
- Species Cross-Reactivity
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Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-147 of human GLRX
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunoprecipitation |  |
||
| Western Blotting | |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- P35754
- Entrez Gene
- GLRX
- GO Terms
- GO:0009055 electron carrier activity
- GO:0005829 cytosol
- GO:0045454 cell redox homeostasis
- GO:0022900 electron transport chain
- GO:0006810 transport
- GO:0015038 glutathione disulfide oxidoreductase activity
- GO:0015035 protein disulfide oxidoreductase activity
- GO:0015949 nucleobase, nucleoside and nucleotide interconversion
- GO:0047485 protein N-terminus binding
- View More GO Terms
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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