FSCN1 antibody | CPTC29
Mouse anti Human FSCN1 antibody recognizes Fascin, also known as 55 kDa actin-bundling protein, fascin homolog 1, actin-bundling protein, singed-like (fascin homolog, sea urchin).
The FSCN1 gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of FSCN1 is known to be regulated by several microRNAs, and overexpression of FSCN1 may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of FSCN1 is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of FSCN1 is located on the long arm of chromosome 15 (provided by RefSeq, Sep 2011).
Mouse anti Human FSCN1 antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The FSCN1 gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of FSCN1 is known to be regulated by several microRNAs, and overexpression of FSCN1 may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of FSCN1 is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of FSCN1 is located on the long arm of chromosome 15 (provided by RefSeq, Sep 2011).
Mouse anti Human FSCN1 antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti FSCN1 detects a band of approximately 55 kDa in K562 cell lysates
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Recombinant protein of human FSCN1
- Instructions For Use
- Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- As supplied, 12 months from date of despatch.
More Information
- UniProt
- Q16658 Related reagents
- Entrez Gene
- FSCN1 Related reagents
- GO Terms
- GO:0001725 stress fiber
- GO:0030674 protein binding, bridging
- GO:0051015 actin filament binding
- GO:0051017 actin filament bundle assembly
- GO:0005737 cytoplasm
- GO:0008144 drug binding
- GO:0008283 cell proliferation
- GO:0016477 cell migration
- GO:0030054 cell junction
- GO:0030175 filopodium
- Acknowledgements
- PrecisionAb™ is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of FSCN1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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