CXCL10 antibody | D03-4F4

Mouse anti Human CXCL10:Biotin

Product Type
Monoclonal Antibody
Clone
D03-4F4
Isotype
IgG1
Specificity
CXCL10

Product Code Applications Pack Size List Price Your Price Qty
MCA6189B
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.1 mg loader
List Price Your Price
loader
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Mouse anti Human CXCL10 antibody, clone D03-4F4, recognizes Chemokine C-X-C ligand 10 (CXCL10), also known as interferon-γ-inducible protein 10 (IP-10), is a member of the C-X-C subfamily of chemokines. CXCL10 can be secreted by leukocytes, neutrophils, monocytes, endothelial cells, fibroblasts, thyrocytes and keratinocytes. CXCL10 plays a role in the recruitment of immune cells expressing its specific receptor, CXCR3. Beyond regulating immune cell migration, CXCL10 also plays a role in regulating cell growth and angiogenesis inhibition during tissue injury, development and maintenance. Under normal physiological conditions, CXCL10 is usually undetectable in most non-lymphoid tissues. Only upon induction of an immunoinflammatory response through infection or injury is CXCL10 then detected (Muller et al. 2010). As such, CXCL10 has been used as a biomarker of disease severity and as a prognostic indicator for various renal diseases (Gao et al. 2020).

This biotinylated Mouse anti Human CXCL10 antibody, clone D03-4F4 (MCA6189B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CXCL10 antibody, clone A01-2G1 (MCA6188GA) as the capture antibody.

Target Species
Human
Product Form
Purified IgG conjugated to Biotin - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
Immunogen
E. coli derived recombinant human full length CXCL10 (Val22-Pro98)
Approx. Protein Concentrations
IgG concentration 0.1 mg/ml
Fusion Partners
Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
ELISA Matched Pair(s)
ELISA Matched Pair-Capture Antibody: MCA6188GA
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1.0 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Description Product Code Applications Pack Size List Price Your Price Quantity
Mouse anti Human CXCL10 MCA6188GA E 0.1 mg loader
List Price Your Price
loader
Description Mouse anti Human CXCL10

Synonyms
IP-10
UniProt
P02778
Entrez Gene
CXCL10
GO Terms
GO:0005615 extracellular space
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007166 cell surface receptor linked signaling pathway
GO:0007267 cell-cell signaling
GO:0007517 muscle organ development
GO:0008009 chemokine activity
GO:0008015 blood circulation
GO:0008284 positive regulation of cell proliferation
GO:0008603 cAMP-dependent protein kinase regulator activity
View more products with CXCL10 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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