CD52 antibody | Campath-1H

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Human anti CD52 (Alemtuzumab Biosimilar)

Anti-CD52 Antibody is a non-therapeutic biosimilar of the monoclonal antibody drug alemtuzumab (Lemtrada) for research use. It can be used in bioanalytical assays and for studying biological pathways affected by the drug.

Product Type
Monoclonal Antibody
Clone
Campath-1H
Isotype
IgG1
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
MCA6101 E 0.2 mg
Human Anti-CD52 Antibody, clone Campath-1H is a research grade biosimilar of the monoclonal antibody drug alemtuzumab. It is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic antibody Campath-1H.

Human Anti-CD52 Antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-alemtuzumab antibodies, for example HCA198 and HCA175. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-alemtuzumab antibody in IgG1 format as reference standard, for example HCA175.

Alemtuzumab is a drug used in the treatment of chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma (CTCL) and T-cell lymphoma. Alemtuzumab is also used in some conditioning regimes for bone marrow transplantation, kidney transplantation and islet cell transplantation along with clinical trial protocols for treatment of certain autoimmune diseases including multiple sclerosis.

This product is NOT FOR THERAPEUTIC USE.

View a summary of supporting anti-alemtuzumab antibody products

Product Details

Target Species
Human
Product Form
Human IgG1 (kappa) antibody - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Proclin 300
Immunogen
Human lymphocytes
Purity
>98% by SDS PAGE
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
12 months from date of despatch

More Information

UniProt
P31358 Related reagents
Entrez Gene
CD52 Related reagents
GO Terms
GO:0005887 integral to plasma membrane
GO:0005624 membrane fraction
GO:0007204 elevation of cytosolic calcium ion concentration
GO:0031225 anchored to membrane
GO:0045730 respiratory burst
Licensed Use
For in vitro research purposes only. Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals.
Regulatory
For research purposes only

Applications of CD52 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Useful Reagents Available

Description Product Code Pack Size Applications List Price Quantity
Hispec Assay Diluent BUF049A 50 ml E IY
LYNX Rapid HRP Antibody Conjugation Kit LNK002P 3 Conjugations For 400µg Antibody CJ