Mouse anti Human CCL20 antibody, clone O03-3H12,
recognizes C-C motif chemokine 20, also known as LARC, MIP3A, and SCYA20. The chemokine CCL20 is expressed mostly in the lymphatic tissue, lung, and liver, and is produced by cells involved with the inflammatory and immune responses. CCL20 plays an important role in recruiting inflammatory cells to the site of infection or injury (Soto et al. 2017
). However, CCL20 is involved with pathogenesis of chronic inflammatory disorders, specifically interstitial lung fibrosis and chronic obstructive pulmonary disease (COPD), and can contribute to tumor metastasis (Zhang et al. 2017
). Inhibition of CCL20, along with its ligand CCR6, might have valuable therapeutic potential for treatment of autoimmune and inflammatory diseases, and is therefore a target of interest for drug discovery (Ranasinghe and Eri 2018
The biotinylated Mouse anti Human CCL20 antibody, clone O03-3H12 (MCA6203B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL20 antibody, clone J03-4D4 (MCA6202GA
) as the capture antibody.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CCL20 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.