Mouse anti Human CCL17 antibody, clone I11-2A1
recognizes C-C motif chemokine 17, also known as TARC and SCYA17. CCL17 is a C-C chemokine highly expressed by the thymus and other cell types, including fibroblasts (Li et al. 2019
). CCL17 induces and enhances a broad spectrum of immune reactions, including some contact hypersensitivity reactions, allograft rejections, inflammatory bowel disease, atopic dermatitis and atherosclerosis (Scheu et al. 2017
). Therapeutic use of antibodies to neutralize CCL17 can block influx of T cells and ameliorate the impact of various diseases (Teplyakov et al. 2017
). Upregulation of CCL17 has been reported in breast cancer, and predicts a decrease in overall survival for patients with breast cancer (Li et al. 2019
The biotinylated Mouse anti Human CCL17 antibody, clone I11-2A1 (MCA6181B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL17 antibody, clone I02-2A4 (MCA6180GA
) as the capture antibody.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CCL17 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.