CCL17 antibody | I11-2A1

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Mouse anti Human CCL17:Biotin

Product Type
Monoclonal Antibody
Clone
I11-2A1
Isotype
IgG1
Product Code Applications Pack Size List Price Quantity
MCA6181B
Datasheet
IY
SDS
0.1 mg loader

Mouse anti Human CCL17 antibody, clone I11-2A1recognizes C-C motif chemokine 17, also known as TARC and SCYA17. CCL17 is a C-C chemokine highly expressed by the thymus and other cell types, including fibroblasts (Li et al. 2019). CCL17 induces and enhances a broad spectrum of immune reactions, including some contact hypersensitivity reactions, allograft rejections, inflammatory bowel disease, atopic dermatitis and atherosclerosis (Scheu et al. 2017). Therapeutic use of antibodies to neutralize CCL17 can block influx of T cells and ameliorate the impact of various diseases (Teplyakov et al. 2017). Upregulation of CCL17 has been reported in breast cancer, and predicts a decrease in overall survival for patients with breast cancer (Li et al. 2019).

The biotinylated Mouse anti Human CCL17 antibody, clone I11-2A1 (MCA6181B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL17 antibody, clone I02-2A4 (MCA6180GA) as the capture antibody.

Product Details

Target Species
Human
Product Form
Purified IgG conjugated to Biotin - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
Immunogen
E. coli derived recombinant human full length CCL17 (Ala24-Ser94)
Approx. Protein Concentrations
IgG concentration 0.1 mg/ml
Fusion Partners
Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
Q92583
Entrez Gene
CCL17
GO Terms
GO:0005615 extracellular space
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor protein signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0008009 chemokine activity
Regulatory
For research purposes only

Applications of CCL17 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoassay 1.0 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Useful Reagents Available

Description Product Code Applications Pack Size List Price Quantity
Mouse anti Human CCL17 MCA6180GA IY 0.1 mg loader

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