Aldehyde Dehydrogenase 2 antibody | 4G6A3

Mouse anti Aldehyde Dehydrogenase 2

Product Type
PrecisionAb Monoclonal
Clone
4G6A3
Isotype
IgG1
Format
Purified
Specificity
Aldehyde Dehydrogenase 2

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VMA00235
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Mouse anti Human aldehyde dehydrogenase 2 antibody recognizes aldehyde dehydrogenase, mitochondrial, also known as ALDH class 2, acetaldehyde dehydrogenase 2, aldehyde dehydrogenase, mitochondrial, liver mitochondrial ALDH and nucleus-encoded mitochondrial aldehyde dehydrogenase 2.

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. ALDH2 encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms (provided by RefSeq, Mar 2011).

Mouse anti Human aldehyde dehydrogenase 2 antibody detects a band of 56 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti aldehyde dehydrogenase 2 detects a band of approximately 56 kDa in HepG2 cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid.
Preparation
Mouse monoclonal antibody prepared by affinity chromatography on Protein G from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
Recombinant protein corresponding to amino acids 317-517 of human aldehyde dehydrogenase 2 expressed in E. coli
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P05091
Entrez Gene
ALDH2
GO Terms
GO:0009055 electron carrier activity
GO:0042136 neurotransmitter biosynthetic process
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0005759 mitochondrial matrix
GO:0005975 carbohydrate metabolic process
GO:0006069 ethanol oxidation
GO:0006805 xenobiotic metabolic process
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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