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IL-23 Receptor Antibody

IL-23 Receptor Antibody gallery image 1

Paraffin embedded human spleen stained with Goat anti human IL-23 Receptor (AHP1821)

IL-23 Receptor Antibody gallery image 2

Paraffin embedded mouse spleen stained with Goat anti human IL-23 Receptor (AHP1821)

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  • IL-23 Receptor Antibody thumbnail image 2
  • Goat anti Human Interleukin-23 Receptor (N-Terminal)
(Rated 0.0 out of 5 based on 0 customer reviews)
  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    AHP1821P *, WBdatasheet pdfdatasheet pdf0.1 mg
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    • Goat anti Human Interleukin-23 receptor antibody recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kDa single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and posessing two fibronectin type III domains. Multiple potential isoforms formed by alternative splicing are described. Goat anti Human Interleukin-23 receptor antibody recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), precsent in isoforms 1, 3 and 4 (UniProt: Q5VWK5), the anytibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signalling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 (Kistner et al. 2006) and susceptibility to the ulcerative and inflammatory psoriasis (Hüffmeier et al. 2009).

      Goat anti Human Interleukin-23 receptor antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues. .
    • Intended Use
    • Target Species
    • Species Cross-Reactivity
      Target SpeciesCross Reactivity
      N.B. Antibody reactivity and working conditions may vary between species.
    • Product Form
      Purified IgG - liquid
    • Reconstitution
    • Preparation
    • Antiserum Preparation
      Antiserum to human IL-23R (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
    • Preservative Stabilisers
      0.1% Sodium Azide (NaN3)
      0.1% Bovine Serum Albumin
    • Immunogen
      Synthetic peptide CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-terminal region of human IL-23 receptor.
    • Purity
    • Approx. Protein Concentrations
      IgG concentration 1.0mg/ml
    • Reagents In The Kit
    • Preparing The Antibody
    • Test Principle
    • Buffer Solution
      Phosphate buffered saline
    • Storage
      Store at +4oC or at -20oC if preferred.
      Storage in frost-free freezers is not recommended.
      This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
    • Shelf Life
      18 months from date of despatch.
    • GO Terms
      innate immune response
      receptor activity
      inflammatory response
      plasma membrane
      integral to membrane
    • UniProt
    • Entrez Gene
    • Acknowledgements
    • Regulatory
      For research purposes only
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Western Blotting1/500
      Immunohistology - Paraffin(1)1/125
      This product requires antigen retrieval using heat treatment prior to staining of paraffin sections

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional IL-23 Receptor Antibody Formats

    Formats Applications Sizes available
    IL-23 Receptor Antibody : Purified P *, WB 0.1 mg
    • Copyright © 2016 Bio-Rad

    Recommended Secondary Antibody

      DescriptionProduct CodePack SizeApplicationsList PriceQuantity
      Rabbit anti Goat IgG (Fc):FITCSTAR122F1 mgF
      Rabbit anti Goat IgG (Fc):HRPSTAR122P1 mgC, E, WB

      Recommended Negative Isotype Control

        Useful Reagents

          DescriptionProduct CodePack SizeApplicationsList PriceQuantity
          Antigen Retrieval Buffer, pH8.0BUF025C50 mlP
          Antigen Retrieval Buffer, pH8.0BUF025A500 mlP

          Recommended Positive Controls

            Histology Controls

                • Product Images

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                • IL-23 Receptor Antibody thumbnail image 2

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