Alpha 1 antitrypsin (A1AT) is a glycoprotein of MW 54 kDa with a pI of 4.8. It is a serine protease inhibitor that acts to limit the amount of cell damage and death at the tissue site. Different isoenzymes exist which together form the Protease inhibitor system. Phenotype M is the most common and certain variants (S and Z) are associated with A1AT deficiency which can lead to emphysema and liver disease.
- Target Species
- Product Form
- Purified alpha 1 antitrypsin from human serum - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- SDS PAGE: >96%
Identity was confirmed by radial immunodiffusion, SDS-PAGE and cellulose acetate electrophoresis.
- Approx. Protein Concentrations
- 2.0 mg/ml
- Protein Molecular Weight
- 54 kDa
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Alpha 1 Antitrypsin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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