Published customer image: Enlarge
TDP-43 pathological and glycine to proline mutant peptides exhibit different neurotoxicity. (A) The comparison of cell viability in the presence of D1, G294V, G295S, GGG294PPP, and GGG308PPP for 72 hours determined by AlamarBlue assay. Results were means ± SEM of three independent experiments (* = p<0.05, ** = p<0.01, N.S. = not significant). (B) Time-lapse DIC microscopy of N2a cell after the addition of PBS, GGG308PPP, or G295S for 36 hours.
From: Sun C-S, Wang CY-H, Chen BP-W, He R-Y, Liu GC-H, et al. (2014) The Influence of Pathological Mutations and Proline Substitutions in TDP-43 Glycine-Rich Peptides on Its Amyloid Properties and Cellular Toxicity. PLoS ONE 9(8): e103644.