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IgM

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Human IgM Purified Immunoglobulin

Product Type
Purified Protein
Isotype
IgM
Specificity
IgM

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OBT1524
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Human IgM Purified Immunoglobulin is purified IgM from myeloma serum. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-human serum and anti-human IgM (µ chain specific). No reaction was observed against anti-human IgG F(c). Some light chain cross reactivity will occur with human IgG.

Target Species
Human
Product Form
Purified Protein - liquid
Preparation
Purified IgM prepared by delipidation, selective precipitation and tandem molecular sieve chromatography.
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
0.1% Sodium Azide (NaN3)
Approx. Protein Concentrations
1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only.

References for IgM

  1. Litvack, M.L. et al. (2010) Natural IgM and innate immune collectin SP-D bind to late apoptotic cells and enhance their clearance by alveolar macrophages in vivo.
    Mol Immunol.48: 37-47.
  2. Cui, X. et al. (2016) Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability.
    Leukemia. 30 (1): 74-85.
  3. Augé, E. et al. (2017) New perspectives on corpora amylacea in the human brain.
    Sci Rep. 7: 41807.
  4. Augé, E. et al. (2018) Astrocytes and neurons produce distinct types of polyglucosan bodies in Lafora disease.
    Glia. 66 (10): 2094-107.
  5. Riba, M. et al. (2019) Corpora amylacea act as containers that remove waste products from the brain.
    Proc Natl Acad Sci U S A. 116 (51): 26038-48.
  6. Riba, M. et al. (2022) Wasteosomes (corpora amylacea) of human brain can be phagocytosed and digested by macrophages.
    Cell Biosci. 12 (1): 177.

RRID
AB_615619
UniProt
P01871
Entrez Gene
IGHM
GO Terms
GO:0003823 antigen binding
GO:0016021 integral to membrane
GO:0005624 membrane fraction

OBT1524

153349 159681 164066

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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