IL-1 Alpha
Recombinant Bovine interleukin-1 alpha (IL-1α) is a recombinant protein corresponding to aa 120-268 of native bovine IL-1α.
Interleukin-1α is a pleiotropic pro-inflammatory cytokine and member of the IL-1 superfamily. It is secreted by activated macrophages and monocytes and is involved in the modulation of a wide range of immune and inflammatory responses.
IL-1α and the closely related IL-1β, are both involved in haematopoiesis and exhibit many identical immunomodulatory properties, binding to the same type I interleukin-1 receptor, also known as CD121a.
Interleukin-1α is a pleiotropic pro-inflammatory cytokine and member of the IL-1 superfamily. It is secreted by activated macrophages and monocytes and is involved in the modulation of a wide range of immune and inflammatory responses.
IL-1α and the closely related IL-1β, are both involved in haematopoiesis and exhibit many identical immunomodulatory properties, binding to the same type I interleukin-1 receptor, also known as CD121a.
Product Details
- Target Species
- Bovine
- Product Form
- Purified recombinant protein - lyophilized
- Reconstitution
- Reconstitute with 20 μl sterile PBS containing 0.1% carrier protein
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution. - Preparation
- Recombinant protein expressed in Pichia pastoris and purified by ion-exchange chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 10% Trehalose
- Purity
- >95% by SDS PAGE analysis
- Protein Molecular Weight
- 17.1 kDa
Storage Information
- Storage
- Prior to reconstitution store at -20oC.
After reconstitution store at -20oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. - Shelf Life
- 12 months from date of despatch
More Information
- UniProt
- P08831 Related reagents
- Entrez Gene
- IL1A Related reagents
- GO Terms
- GO:0001660 fever generation
- GO:0005829 cytosol
- GO:0005125 cytokine activity
- GO:0005149 interleukin-1 receptor binding
- GO:0005507 copper ion binding
- GO:0005615 extracellular space
- GO:0006955 immune response
- GO:0034605 cellular response to heat
- GO:0046688 response to copper ion
- GO:0051781 positive regulation of cell division
- Regulatory
- For research purposes only
Applications of IL-1 Alpha
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | |||
| Functional Assays |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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