Sheep anti Human Transferrin
- Product Type
- Polyclonal Antibody
- Polyclonal IgG
|Sheep anti Human transferrin antibody recognizes human transferrin, also known as beta-1 metal-binding globulin
siderophilin or serotransferrin. Transferrin is 647 amino acid ~79 kDa iron binding transport glycoprotein involved in iron translocation from sites of degradation to those of of storage and utilization.
Mutations in the TF gene can lead to the iron overload disorder Atransferrinemia (ATRAF) a disease characterized abnormal transferrin production, iron overload and microcytic hypochromic anemia (Knisely et al. 2004).
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Goat Guinea Pig Chicken Mouse Bovine Rabbit Pig Rat Dog Horse Cat
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human transferrin were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG was prepared by ion exchange chromatography.
- Buffer Solution
- Glycine buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
1 mM EDTA
- Human holo-transferrin.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
References for Transferrin antibody
Kwon, E.E. & Prineas, J.W. (1994) Blood-brain barrier abnormalities in longstanding multiple sclerosis lesions. An immunohistochemical study.
J Neuropathol Exp Neurol. 53 (6): 625-36.
Pak, S.C. et al. (1996) Super-CHO-A cell line capable of autocrine growth under fully defined protein-free conditions.
Cytotechnology. 22 (1-3): 139-46.
Sunstrom, N.A. et al. (2000) Regulated autocrine growth of CHO cells.
Cytotechnology. 34 (1-2): 39-46.
Navarro-garcía, F. et al. (2007) Intoxication of epithelial cells by plasmid-encoded toxin requires clathrin-mediated endocytosis.
Microbiology. 153 (Pt 9): 2828-38.
Tirosh, B. et al. (2009) Transferrin as a luminal target for negatively charged liposomes in the inflamed colonic mucosa.
Mol Pharm. 6 (4): 1083-91.
- Entrez Gene
- GO Terms
- GO:0002576 platelet degranulation
- GO:0005576 extracellular region
- GO:0005769 early endosome
- GO:0005770 late endosome
- GO:0030141 stored secretory granule
- GO:0030139 endocytic vesicle
- GO:0005905 coated pit
- GO:0006879 cellular iron ion homeostasis
- GO:0008199 ferric iron binding
- View More GO Terms
- GO:0009925 basal plasma membrane
- GO:0010008 endosome membrane
- GO:0016324 apical plasma membrane
- GO:0030168 platelet activation
- GO:0033572 transferrin transport
- GO:0048471 perinuclear region of cytoplasm
- GO:0055037 recycling endosome
- GO:0055085 transmembrane transport
Always be the first to know.
When we launch new products and resources to help you achieve more in the lab.Yes, sign me up