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TDP-43 antibody

Goat anti TDP-43

Product Type
PrecisionAb Polyclonal
Polyclonal IgG

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Goat anti Human TDP-43 antibody recognizes human TAR DNA-binding protein 43, also known as TDP-43, the product of the TAR DNA-binding protein 43 gene. TDP-43 is a 414 amino acid DNA and RNA binding protein containing 2 RRM domains involved in regulation of transcription and splicing. TDP-43 is ubiquitously expressed with high levels being seen in pancreas, gall bladder, alimentary tract, reproductive system, adipose tissue, skin and skeletal muscle.

Mutations in the TPD43 gene are implicated in development of Amyotrophic lateral sclerosis 10, a neurodegenerative disorder affecting motor neurons leading to eventual fatal paralysis (Van Deerlin et al. 2008).

Goat anti Human TDP-43 antibody recognizes human TDP-43 as a single band of ~45kDa in multiple cell line lysates by western blotting under reducing conditions. The antibody also cross-reacts with rodent cell line lysates tested.
PrecisionAb Antibodies

Target Species
Western Blotting
Anti TDP-43 antibody detects a band of approximately 45 kDa in NIH/3T3 cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Goat polyclonal antibody purified by ammonium sulfate precipitation followed by antigen affinity chromatography.
Buffer Solution
TRIS buffered saline.
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin
Peptide sequence C-HISNAEPKHNSNRQ from an internal region of TDP-43.
For research purposes only.
12 months from date of despatch.
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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