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LRRK2 antibody

Goat anti LRRK2

Product Type
PrecisionAb Polyclonal
Polyclonal IgG

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Goat anti Human LRRK2 antibody recognizes leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), also known as dardarin.

LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in LRRK2 have been associated with Parkinson disease-8 (provided by RefSeq, Jul 2008).

Goat anti Human LRRK2 antibody detects a band of 286 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Western Blotting
Anti LRRK2 detects a band of approximately 286 kDa in HeLa cell lysates.
Product Form
Purified IgG - liquid
Goat polyclonal antibody purified by affinity chromatography.
Buffer Solution
TRIS buffered saline.
Preservative Stabilisers
0.02% Sodium Azide (NaN3) 0.5 % BSA
Peptide with the sequence CELAEKMRRTSV, from the internal region of the protein sequence.
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
For research purposes only.
12 months from date of despatch.
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Entrez Gene
GO Terms
GO:0000186 activation of MAPKK activity
GO:0004708 MAP kinase kinase activity
GO:0005096 GTPase activator activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0006979 response to oxidative stress
GO:0007264 small GTPase mediated signal transduction
GO:0007528 neuromuscular junction development
GO:0008340 determination of adult lifespan
GO:0018105 peptidyl-serine phosphorylation
GO:0031398 positive regulation of protein ubiquitination
GO:0032473 external side of mitochondrial outer membrane
GO:0034211 GTP-dependent protein kinase activity
GO:0040012 regulation of locomotion
GO:0042803 protein homodimerization activity
GO:0043068 positive regulation of programmed cell death
GO:0046777 protein autophosphorylation
GO:0070997 neuron death


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