LRRK2 antibody

100% Secure


Goat anti LRRK2

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00118
Datasheet
WB
MSDS
100 µl

Goat anti Human LRRK2 antibody recognizes leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), also known as dardarin.

LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in LRRK2 have been associated with Parkinson disease-8 (provided by RefSeq, Jul 2008).

Goat anti Human LRRK2 antibody detects a band of 286 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti LRRK2 detects a band of approximately 286 kDa in HeLa cell lysates.
Product Form
Purified IgG - liquid
Preparation
Goat polyclonal antibody purified by affinity chromatography.
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3) 0.5 % BSA
Immunogen
Peptide with the sequence CELAEKMRRTSV, from the internal region of the protein sequence.

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
Guarantee
12 months from date of despatch

More Information

UniProt
Q5S007
Entrez Gene
LRRK2
GO Terms
GO:0000186 activation of MAPKK activity
GO:0004708 MAP kinase kinase activity
GO:0005096 GTPase activator activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0006979 response to oxidative stress
GO:0007264 small GTPase mediated signal transduction
GO:0007528 neuromuscular junction development
GO:0008340 determination of adult lifespan
GO:0018105 peptidyl-serine phosphorylation
GO:0031398 positive regulation of protein ubiquitination
GO:0032473 external side of mitochondrial outer membrane
GO:0034211 GTP-dependent protein kinase activity
GO:0040012 regulation of locomotion
GO:0042803 protein homodimerization activity
GO:0043068 positive regulation of programmed cell death
GO:0046777 protein autophosphorylation
GO:0070997 neuron death
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of LRRK2 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Donkey anti Sheep/Goat IgG:HRP STAR88P C E P WB 1 ml loader

A Precise Solution to  Reproducible Western Blots - PrecisionAb  Antibodies
Mitochondrial dynamics logo

New Mitochondrial Dynamics Poster

Learn about the mitochondrial fusion-division cycle and how aberrant regulation results in disease

Download or order your free poster