LRRK2 antibody
Goat anti LRRK2
- Product Type
- PrecisionAb Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- LRRK2
Antibody Quality and Performance Guarantee
| Goat anti Human LRRK2 antibody recognizes leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), also known as dardarin. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in LRRK2 have been associated with Parkinson disease-8 (provided by RefSeq, Jul 2008). Goat anti Human LRRK2 antibody detects a band of 286 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
|
- Target Species
- Human
- Western Blotting
- Anti LRRK2 detects a band of approximately 286 kDa in HeLa cell lysates.
- Product Form
- Purified IgG - liquid
- Preparation
- Goat polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- TRIS buffered saline.
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3) 0.5 % BSA
- Immunogen
- Peptide with the sequence CELAEKMRRTSV, from the internal region of the protein sequence.
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
- UniProt
- Q5S007
- Entrez Gene
- LRRK2
- GO Terms
- GO:0000186 activation of MAPKK activity
- GO:0004708 MAP kinase kinase activity
- GO:0005096 GTPase activator activity
- GO:0005524 ATP binding
- GO:0005525 GTP binding
- GO:0006979 response to oxidative stress
- GO:0007264 small GTPase mediated signal transduction
- GO:0007528 neuromuscular junction development
- GO:0008340 determination of adult lifespan
- View More GO Terms
- GO:0018105 peptidyl-serine phosphorylation
- GO:0031398 positive regulation of protein ubiquitination
- GO:0032473 external side of mitochondrial outer membrane
- GO:0034211 GTP-dependent protein kinase activity
- GO:0040012 regulation of locomotion
- GO:0042803 protein homodimerization activity
- GO:0043068 positive regulation of programmed cell death
- GO:0046777 protein autophosphorylation
- GO:0070997 neuron death
VPA00118
120115
167736
168543
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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