LRRK2 antibody

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Goat anti LRRK2

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified

Product Code	Applications	Pack Size	Your Price	List Price	Quantity
VPA00118 Datasheet	WB MSDS	100 µl	Log in		Get Quote

Summary
Secondary Antibodies

Goat anti Human LRRK2 antibody recognizes leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), also known as dardarin.

LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in LRRK2 have been associated with Parkinson disease-8 (provided by RefSeq, Jul 2008).

Goat anti Human LRRK2 antibody detects a band of 286 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species: Human
Western Blotting: Anti LRRK2 detects a band of approximately 286 kDa in HeLa cell lysates.
Product Form: Purified IgG - liquid
Preparation: Goat polyclonal antibody purified by affinity chromatography.
Buffer Solution: TRIS buffered saline
Preservative Stabilisers: 0.02% Sodium Azide (NaN₃) 0.5 % BSA
Immunogen: Peptide with the sequence CELAEKMRRTSV, from the internal region of the protein sequence.

Storage Information

Storage: Store undiluted at -20^oC, avoiding repeated freeze thaw cycles.
Guarantee: 12 months from date of despatch

More Information

UniProt: Q5S007
Entrez Gene: LRRK2
GO Terms: GO:0000186 activation of MAPKK activity; GO:0004708 MAP kinase kinase activity; GO:0005096 GTPase activator activity; GO:0005524 ATP binding; GO:0005525 GTP binding; GO:0006979 response to oxidative stress; GO:0007264 small GTPase mediated signal transduction; GO:0007528 neuromuscular junction development; GO:0008340 determination of adult lifespan; GO:0018105 peptidyl-serine phosphorylation; GO:0031398 positive regulation of protein ubiquitination; GO:0032473 external side of mitochondrial outer membrane; GO:0034211 GTP-dependent protein kinase activity; GO:0040012 regulation of locomotion; GO:0042803 protein homodimerization activity; GO:0043068 positive regulation of programmed cell death; GO:0046777 protein autophosphorylation; GO:0070997 neuron death
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory: For research purposes only

Applications of LRRK2 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.