IgA antibody


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E ResetGoat anti Human IgA:Alk. Phos.
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- IgA
Goat anti Human IgA antibody recognizes the heavy chain of human IgA as demonstrated by ELISA and Flow cytometry. IgA is the major catagory of antibody present in mucosal secretions and acts as a first line of defense against inhaled or ingested pathogens at the mucosal interface. IgA is also present in serum where it acts to eliminate pathogens via interaction with FcαR, also known as CD89. (Woof et al. 2004). Biotinylated Goat anti Human IgA antibody (205008) has been cross-adsorbed against human IgD, IgG and IgM to ensure class specificity. |
- Target Species
- Human
- Product Form
- Purified IgG conjugated to Alkaline Phosphatase - liquid
- Preparation
- Purified IgG prepared by affinity chromatography
- Antiserum Preparation
- Antisera to human IgA were raised by repeated immunisations of goats with highly purified antigen.
- Buffer Solution
- TRIS buffered saline, 1mM MgCl2
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
50% Glycerol - Immunogen
- Human IgA.
- Regulatory
- For research purposes only
- Guarantee
- Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
1/2000 | 1/4000 |
References for IgA antibody
-
Wright, A.K. et al. (2012) Human Nasal Challenge with Streptococcus pneumoniae Is Immunising in the Absence of Carriage.
PLoS Pathog. 8: e1002622. -
Pennington, S.H. et al. (2016) Polysaccharide-specific Memory B-cells Predict Protection Against Experimental Human Pneumococcal Carriage.
Am J Respir Crit Care Med. Jul 12. [Epub ahead of print] -
Turner, P.J. et al. (2020) Differences in nasal immunoglobulin A responses to influenza vaccine strains after live attenuated influenza vaccine (LAIV) immunization in children.
Clin Exp Immunol. 199 (2): 109-118. -
Cole, M.E. et al. (2021) Pre-existing influenza-specific nasal IgA or nasal viral infection does not affect live attenuated influenza vaccine immunogenicity in children.
Clin Exp Immunol. 204 (1): 125-133.
- RRID
- AB_609670
- UniProt
- P01876
- P01877
- Entrez Gene
- IGHA1
- IGHA2
- GO Terms
- GO:0005515 protein binding
- GO:0003823 antigen binding
- GO:0006955 immune response
- GO:0018298 protein-chromophore linkage
- GO:0005624 membrane fraction
205004

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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