Haptoglobin antibody

Sheep anti Human Haptoglobin

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Haptoglobin

Product Code Applications Pack Size List Price Your Price Qty
4890-0004
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 1 ml
List Price Your Price
Search for Batch Specific Datasheets

Sheep anti Human Haptoglobin antibody detects haptoglobin, also known as Hp, an acute phase plasma glycoprotein synthesized by the liver in response to infection or inflammation. Haptoglobin binds haemoglobin released by erythrocytes with high affinity, and functions to block the oxidative activity of haemoglobin and prevent renal damage. The haptoglobin-haemoglobin complex is rapidly removed from the circulation by monocytes and macrophages, via the receptor CD163.

The haptoglobin genotype is an independent risk factor for cardiovascular disease (Levy et al. 2002).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Native, purified human haptoglobin from serum.
Approx. Protein Concentrations
IgG concentration 5.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

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References for Haptoglobin antibody

  1. Carter, K. & Worwood, M. (2007) Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases.
    Int J Lab Hematol. 29 (2): 92-110.
  2. Guetta, J. et al. (2007) Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin.
    Atherosclerosis. 191: 48-53.
  3. Araki, H. et al. (2015) Haptoglobin promoter polymorphism rs5472 as a prognostic biomarker for peptide vaccine efficacy in castration-resistant prostate cancer patients.
    Cancer Immunol Immunother. 64 (12): 1565-73.
  4. Soejima, M. et al. (2014) Genetic factors associated with serum haptoglobin level in a Japanese population.
    Clin Chim Acta. 433: 54-7.

RRID
AB_618599
UniProt
P00738
Entrez Gene
HP
GO Terms
GO:0006952 defense response
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0006508 proteolysis
GO:0006879 cellular iron ion homeostasis
GO:0010942 positive regulation of cell death
GO:0030492 hemoglobin binding
GO:0051354 negative regulation of oxidoreductase activity
GO:2000296 negative regulation of hydrogen peroxide catabolic process
View more products with HAPTOGLOBIN specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products